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Title:: -

作者:: 王杨凯; 任安经; 袁文俊; 第二军医大学基础医学部生理学教研室，上海 200433

Author(s):: -

关键词:: 瞬时受体势通道; 钙内流; 内皮细胞; 血管张力

Keywords:: -

分类号:: R543;R331.32

DOI:: -

文献标识码:: A

摘要:: 血管内皮细胞上的瞬时受体势（transient receptor potential,TRP）通道参与血管张力等多种功能的调节，如TRPC1、TRPC4、TRPC6和TRPV1参与血管通透性的调节，TRPC4、TRPV1和TRPV4参与血管张力的调节，TRPC4参与了低氧诱导的血管重构，TRPC3、TRPC4和TRPM2则参与氧化应激诱导的应答。各种TRP通道的激活和调节模式存在很大差异，不同的TRP通道可能由特定的刺激激活，如血管活性物质、氧化应激、机械刺激和加热。TRP通道可能将这些刺激转换成胞内Ca2＋的变化，进而引起不同的血管反应。TRP通道功能失调可引起多种心血管系统疾病。阐明调节内皮TRP通道的机制，开发以不同亚型的TRP通道为靶点的特异性药物，有望为心血管疾病的治疗开辟新的前景。

Abstract:: -

参考文献/References

［1］ Paria BC, Vogel SM, Ahmmed GU, et al. Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability［J］. Am J Physiol Lung Cell Mol Physiol, 2004, 287(6):L1303-L1313.

［2］ Nilius B, Vriens J, Prenen J, et al. TRPV4 calcium entry channel: a paradigm for gating diversity［J］. Am J Physiol Cell Physiol, 2004, 286(2):C195-C205.

［3］ Domenicali M, Ros J, Fernandez-Varo G, et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors［J］. Gut, 2005, 54(4):522-527.

［4］ Nilius B, Droogmans G, Wondergem R. Transient receptor potential channels in endothelium: solving the calcium entry puzzle?［J］.Endothelium, 2003, 10(1):5-15.

［5］ Jho D, Mehta D, Ahmmed G, et al. Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2+ influx［J］. Circ Res, 2005, 96(12):1282-1290.

［6］ Tiruppathi C, Ahmmed GU, Vogel SM, et al. Ca2+signalinh,TRP channels,and endohelial permeability［J］. Microcirculation, 2006, 13(8):693-708.

［7］ Pocock TM, Foster RR, Bates DO. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo［J］. Am J Physiol Heart Circ Physiol, 2004, 286(3):H1015-H1026.

［8］ Aarts M, Iihara K, Wei WL, et al. A key role for TRPM7 channels in anoxic neuronal death［J］. Cell, 2003, 115(7):863-877.

［9］ Kwan HY, Leung PC, Huang Y, et al . Depletion of intracellular Ca2+stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells［J］. Circ Res, 2003, 92(3):286-292.

［10］Gao X, Wu L, O’Neil RG. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and-independent pathways［J］. J Biol Chem, 2003, 278(29):27129-27137.

［11］Devuyst O, Persu A, Vo-cong MT. Autosomal dominant polycystic kidney disease: modifier genes and endothelial dysfunction［J］. Nephrol Dial Transplant, 2003, 18(11):2211-2215.

［12］Hisatsune C, Kuroda Y, Nakamura K, et al. Regulation of TRPC6 channel activity by tyrosine phosphorylation［J］. J Biol Chem, 2004, 279(18):18887-18894.

［13］Vazquez G, Wedel BJ, Kawasaki BT, et al. Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels［J］. J Biol Chem, 2004, 279(39):40521-40528.

［14］Nagy I, Sntha P, Jancsó G,et al . The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology［J］.Eur J Pharmacol, 2004, 500(1-3):351-369.

［15］Kohier R, Heyken WT, Heinau P. Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation［J］. ArteriosclerThrombVascBiol,2006,26(7):1495-1502.

［16］Okuhara DY, Hsis AY, Xie M. Transient receptor potential channels as drug targets［J］. Expert Opin Ther Targets, 2007, 11(3):391-401.

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血管内皮细胞瞬时受体势通道的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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