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¡¶ÐÄÔàÔÓÖ¾¡·[ISSN:1009-7236/CN:61-1268/R]

ÆÚÊý:

2009ÄêµÚ5ÆÚ

Ò³Âë:

678-680

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2009-07-14

ÎÄÕÂÐÅÏ¢/Info

Title:

Effect of permanent cardiac pacing on brain natriuretic peptide and the intervention of benazepril

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Ìï·É·É¹; ËïÏþì³²; Îä×ÚÒú²; Ñ²; Îº×ÓÐã²

1.ɽ¶«Ê¡Ò½Ñ§¿ÆѧԺ£¬É½¶« ¼ÃÄÏ 250062£»2.¼ÃÄþÊеÚÒ»ÈËÃñÒ½ÔºÐÄÔàÖÐÐÄ£¬É½¶« ¼ÃÄþ 272013

Author(s):

TIAN Fei-fei¹;  SUN Xiao-fei²;  WU Zong-yin²;  YANG Jian²;  WEI Zi-xiu²

1.Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China; 2.Center of Cardiology, Jining First People¥“s Hospital, Jining 272013, Shandong, China

¹Ø¼ü´Ê:

ÓÀ¾ÃÐÔÐÄÔàÆð²«; ÄÔÄÆÄòëÄ; ±´ÄÇÆÕÀû

Keywords:

permanent cardiac pacing;  brain natriuretic peptide;  benazepril

·ÖÀàºÅ:

R541.62

DOI:

-

ÎÄÏ×±êʶÂë:

A

ÕªÒª:

Ä¿µÄ: Ñо¿²»Í¬Æð²«Ä£Ê½¡¢²»Í¬ÐÄÊÒÆ𲫰ٷֱȶÔÓÀ¾ÃÐÔÐÄÔàÆ𲫻¼ÕßѪ½¬ÄÔÄÆÄòëÄ£¨BNP£©Å¨¶ÈµÄÓ°Ï죬¼°±´ÄÇÆÕÀû¶Ô¸ÃÀ໼ÕßÐŦÄܵĸÉÔ¤×÷Ó᣷½·¨: ÈëÑ¡2006Äê1ÔÂ~2007Äê10ÔÂÓÚÎÒÔºÐÐÓÀ¾ÃÐÔÐÄÔàÆ𲫵Ļ¼Õß120Àý£¬ÆäÖÐVVIÆð²«62ÀýDDDÆð²«58Àý£¬ËùÓл¼ÕßËæ»ú·ÖΪ·þÓñ´ÄÇÆÕÀû×飨¸ÉÔ¤×飩¼°Î´·þÓñ´ÄÇÆÕÀû×飨·Ç¸ÉÔ¤×飩£¬Ã¿×é¸ù¾ÝÆð²«Ä£Ê½²»Í¬·ÖΪVVIÆð²«ÑÇ×é¼°DDDÆð²«ÑÇ×é¡£·Ö±ðÓÚÆð²«Ç°¡¢Æ𲫺ó6¸öÔ¼ì²âѪ½¬BNPŨ¶È¡£½á¹û: VVIÆ𲫻¼ÕßѪ½¬BNPŨ¶È´óÓÚDDDÆ𲫻¼Õߣ¨P<0.05£©£»¸ßÐÄÊÒÆ𲫰ٷֱȻ¼ÕßѪ½¬BNPŨ¶È´óÓÚµÍÐÄÊÒÆ𲫰ٷֱȻ¼Õߣ¨P<0.05£©£»¸ÉÔ¤×éѪ½¬BNPŨ¶ÈÏÔÖøµÍÓڷǸÉÔ¤×飨P<0.05£©¡£½áÂÛ: Æ𲫺óѪ½¬BNPŨ¶ÈÔö¼Ó£¬ÇÒËæ×ÅÐÄÊÒÆ𲫰ٷֱȵÄÔö¸ß¶øÔö¸ß£¬µ«DDDÆð²«ÓÅÓÚVVIÆ𲫣»±´ÄÇÆÕÀû¿ÉÒÔÑÓ»ºÓÀ¾ÃÐÔÐÄÔàÆ𲫻¼ÕßѪ½¬BNPŨ¶ÈµÄÔö¼ÓÁ¿¡£

Abstract:

AIM: To investigate the effect of different pacing modes and different cardioventricular pacing percentage on the plasma concentration of brain natriuretic peptide (BNP) and the intervention of benazepril in the pacemaker population. METHODS: One hundred and twenty patients £Ûventricular inhibited (VVI) 62, dual-mode, dual-pacing, dual-sensing (DDD) 58£Ý implanted with permanent cardiac pacing from January 2006 to October 2007 in our hospital were enrolled in the study. Patients were randomized to two groups according to whether or not they were taking benazepril. Each group was subdivided into DDD group and VVI group. Plasma concentrations of BNP were recorded before pacing and 6 months after pacing. RESULTS: Plasma concentration of BNP in VVI pacing was higher than in DDD pacing (P<0.05). Plasma concentration of BNP in high cardioventricular pacing percentage was higher than in low cardioventricular pacing percentage (P<0.05). Plasma concentration of BNP in patients who were taking benazepril were significantly lower than in patients who did not take benazepril (P<0.05). CONCLUSION: Plasma concentration of BNP increases after pacing and increases with the cardioventricular pacing percentage. DDD pacing is superior to VVI pacing. Benazepril can delay the increase of BNP in patients with permanent cardiac pacing.

²Î¿¼ÎÄÏ×/References

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£Û2£Ý Sudoh T, Kangawa K, Minamino N, et al. A new natriuretic peptide in porcine brain£ÛJ£Ý. Nature, 1988, 322(6159):78-81.

£Û3£Ý Remme WJ, Swedberg K. Task force for the Diagnosis and Treatment of Chronic Heart Failure of European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure£ÛJ£Ý. Eur Heart J, 2001, 22(17):1527-1560.

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£Û5£Ý Horie H, Tsutamoto T, Ishimoto N, et al. Plasma brain natriuretic peptide as a biochemicalmarker for atrioventricular sequence in patientswith pacemakers£ÛJ£Ý. PACE, 1999, 22(2):282-290.

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£Û8£Ý Lee MA, Dae MW, Langberg JJ, et al. Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology£ÛJ£Ý. J Am Coll Cardiol, 1994, 24£¨1£©: 225-232.

£Û9£Ý Tse HF, Lau CP. Long term effect of right ventricular pacing on myocardial perfusion and function£ÛJ£Ý. J Am Coll Cardiol, 1997, 29£¨4£©:744-749.

£Û10£ÝNielsen JC, Bottcher M, Nielsen TT, et al. Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing£­effect of pacing mode and rate£ÛJ£Ý. J Am Coll Cardiol, 2000, 35£¨6£©:1453£­1461.

£Û11£ÝSweeney MO, Shea JB, Fox V, et al. Randomized pilot study of a new atrial-based minimal ventricular pacing mode in dual-chamber implantable cardioverter-defibrillators £ÛJ£Ý. Heart Rhythm, 2004, 1(2):160-167.

£Û12£ÝMair J, Lercher A, Puschendorf B. The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure£ÛJ£Ý. Clin Chem Lab Med, 2001, 39 (7):571

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