氨氯地平和依那普利联合治疗高血压病左心室舒张功能不全的疗效
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2009年第5期
- 页码:
- 683-685
- 栏目:
- 临床研究
- 出版日期:
- 2009-07-14
文章信息/Info
- Title:
- Combined administration of levamlodipine and enalapril in treatment of hypertensive patients with left ventricular diastolic dysfunction
- Author(s):
- ZHANG Lei; LI Yao; DAI Zu-rong; JIANG Yi; ZHOU Xia-fei; HUANG Xiu-ping
- Department of Cardiology, First Affiliated Hospital, Chengdu Medical College, Chengdu 610500, Sichuan, China
- 关键词:
- 高血压; 原发性; 舒张功能不全; 钙离子拮抗剂; 血管紧张素转换酶抑制剂
- Keywords:
- hypertension; diastolic dysfunction; calcium channel blocker; angiotensin-converting enzyme inhibitor
- 分类号:
- R972.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的: 研究高血压病患者左室舒张功能不全治疗的最佳方案。方法: 将60例门诊高血压病患者随机分为3组：氨氯地平组给予苯磺酸左旋氨氯地平5 mg每晚1次；依那普利组给予马来酸依那普利10 mg每日2次；联合用药组给予苯磺酸左旋氨氯地平2.5 mg每晚1次＋马来酸依那普利5 mg每日2次。对比治疗前和6个月后随访时的左室射血分数（LVEF）、心电机械图S2至E峰时间（IVRT）、二尖瓣血流峰值速度E/A，并对比各组中不良反应的发生率。结果: 3组内治疗前后LVEF无显著性差异；IVRT、E/A改善具有显著性。3组间治疗后结果比较LVEF、IVRT均无统计学差异，联合用药组E/A较单独用药组具有统计学差异（均P<0.05）。结论: 对伴有左心室舒张功能不全的高血压病患者，氨氯地平和依那普利对舒张功能的指标均有改善；而氨氯地平和依那普利小剂量联合使用，对舒张功能的指标E/A有更显著地改善，且副作用发生率较低。
- Abstract:
- AIM: To explore a better therapy program for hypertensive patients with left ventricular diastolic dysfunction. METHODS: Sixty hypertensive out-patients were randomly divided into three groups: Group 1 treated with levamlodipine besilate (5 mg) nightly, Group 2 treated with enalapril maleate (10 mg) twice daily, and Group 3 treated with levamlodipine besilate (2.5 mg) nightly plus enalapril maleate (5 mg) twice daily. LVEF, IVRT, E/A, and side effects were recorded before treatment and 6 months after treatment. RESULTS: LVEF of the three groups before and after treatment showed no significant differences. IVRT and E/A improved significantly (P<0.05). After treatment, LVEF and IVRT showed no significant difference among the three groups. Compared with that in Group 1 and Group 2, Group 3 E/A was significantly different (P<0.05). CONCLUSION: In the treatment of hypertensive patients with diastolic dysfunction, levamlodipine besilate and enalapril maleate improve the indicator of diastolic function. The combination of low-dose levamlodipine besilate and enalapril maleate significantly improves the E/A with few side effects.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2008-12-9.作者简介：张磊，副主任医师Email：zhl.037@163.com
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