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|本期目录/Table of Contents|

幽门螺杆菌感染与不稳定型心绞痛有关联

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第5期
页码:
715-726,729
栏目:
临床研究
出版日期:
2009-07-14

文章信息/Info

Title:
Relationship between Helicobacter pylori infection and unstable angina pectoris
作者:
张宜青; 万征; 杨振文; 于雪芳; 孙跃民
天津医科大学总医院心内科，天津 300052
Author(s):
ZHANG Yi-qing;  WAN Zheng;  YANG Zhen-wen;  YU Xue-fang;  SUN Yue-min
Department of Cardiology, General Hospital, Tianjin Medical University, Tianjin 300052, China
关键词:
幽门螺杆菌; 心绞痛; 不稳定型; 高敏C反应蛋白
Keywords:
Helicobacter pylori;  unstable angina pectoris;  highly sensitive C-reactive protein
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 观察幽门螺杆菌（Hp）感染是否与不稳定型心绞痛（UAP）有关联。方法: 152例住院的心绞痛患者分为两组：UAP组患者114例，对照组为稳定型心绞痛（SAP）患者38例。所有患者应用ELISA法测定血清Hp-IgG浓度，测定血清高敏C反应蛋白（hsCRP）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）浓度，行冠状动脉造影检查，以Gensini冠状动脉积分评价冠状动脉狭窄程度。结果: UAP组患者的血清Hp-IgG、hsCRP、空腹血糖（FPG）水平和冠状动脉积分均高于SAP组患者（P<0.05），采用多因素Logistic回归分析表明，血清Hp-IgG（OR=5.13，95%CI 1.91-13.78，P<0.01）、hsCRP（OR=3.58，95%CI 1.32-9.65，P<0.05）和FPG（OR=6.20，95%CI 1.21-31.42，P<0.05）水平升高的3个指标与UAP有关。结论: 血清Hp-IgG水平升高与UAP有关。
Abstract:
AIM: To observe the relationship between Helicobacter pylori (Hp) infection and unstable angina pectoris (UAP). METHODS: One hundred and fifty-two patients with angina pectoris from Tianjin Medical University Hospital were divided into UAP group (n=114) and stable angina pectoris group (SAP, n=38). The concentration of the Ig-G antibodies to Hp (Hp-IgG) was determined by enzyme-linked immunosorbent assay (ELISA). The concentration of the high-sensitivity C-reactive protein (hsCRP), total cholesterol (TC), triglyeride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined. Coronary angiography was performed in all patients to assess the degree of coronary artery stenoses. RESULTS: Levels of serum Hp-IgG, hsCRP and FPG were higher in UAP group than in control group. Multivariate logistic regression analysis showed that the higher levels of Hp-IgG (OR=5.13, 95%CI 1.91-13.78, P<0.01), hsCRP (OR=3.58, 95%CI 1.32-9.65, P<0.05) and FPG (OR=6.20, 95%CI 1.21-31.42, P<0.05) were risk factors for UAP patients. CONCLUSION: The concentration of serum Hp-IgG is higher in UAP patients. The higher level of Hp-IgG is significantly associated with UAP.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-11-18.通讯作者：万征，教授，主要从事冠心病介入治疗、心律失常与电生理的研究Email：wanzhhh@yahoo.com.cn 作者简介：张宜青，副主任医师，硕士Email：zhyiq68@yahoo.com.cn
更新日期/Last Update: 2009-07-22