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糖心通对STZ高脂糖尿病大鼠心肌细胞内核转录因子-κB表达的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
798-800,819
栏目:
基础研究
出版日期:
2009-11-05

文章信息/Info

Title:
Effect of tangxintong particles on NF-κB expression in streptozotocin hyperlipemic diabetic rats
作者:
钱秋海1; 刘大文2; 赵懿2; 钱卫斌2; 扈东兵2; 陈文辉2
山东中医药大学:1.附属医院内分泌科，山东 济南 250011，2.临床学院中医内科，山东 济南 250014
Author(s):
QIAN Qiu-hai1;  LIU Da-wen2;  ZHAO Yi2;  QIAN Wei-bin2;  HU Dong-bing2;  CHEN Wen-hui2
1.Department of Endocrinology, Affiliated Hsopital, Jinan 250011, Shandong, China, 2.TCM Internal Department, Clinical Collegy, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China
关键词:
糖心通; 核转录因子-κB; 链脲菌素; 大鼠
Keywords:
tangxintong particles;  NF-κB;  rat
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
目的: 观察糖心通对链脲佐菌素(STZ)诱导的高脂糖尿病模型大鼠心肌细胞内核转录因子-κB（NF-κB）表达的影响。方法: 以腹腔注射STZ并辅以高脂饮食喂养造成STZ高脂糖尿病模型大鼠。采用免疫组织化学染色法观察糖心通对模型大鼠心肌细胞中NF-κB表达的影响。结果: 糖心通能明显抑制糖尿病大鼠心肌细胞内NF-κB的过度表达，且随剂量的增大而增强。结论: 糖心通对高血糖大鼠的心肌有保护作用，此作用可能与其抑制NF-κB的表达有关。
Abstract:
AIM: To observe the effect of tangxintong particles on NF-κB expression in streptozotocin (STZ) hyperlipemic diabetic rats. METHODS: Hyperlipemic diabetic rats were induced by IP injection of STZ and hyperlipemic diet. Distribution of NF-κB in myocardial cells was measured by immunohistochemistry, and the effect of tangxintong particles on the expression of NF-κB was observed. RESULTS: Tangxintong particles dose-dependently inhibited overexpression of NF-κB in myocardial cells of hyperlipemic diabetic rats. CONCLUSION: Tangxintong particles have some protective effect on myocardium of diabetic rats, which may be related to the inhibition of NF-κB expression.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-10-30.通讯作者：钱秋海，教授，主任医师，主要从事中西医结合内分泌代谢疾病研究Email:qianqiuhai@126.com
更新日期/Last Update: 2009-09-30