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|本期目录/Table of Contents|

CD40L和MMPs与冠脉支架介入治疗术后冠脉再狭窄的相关性及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
820-822
栏目:
临床研究
出版日期:
2009-11-05

文章信息/Info

Title:
Effects of CD40L and matrix metalloproteinses on in-stent restenosis in coronary artery
作者:
张庆成; 汪承炜; 张向峰
武警上海总队医院心血管内科，上海 201103
Author(s):
ZHANG Qing-cheng;  WANG Cheng-wei;  ZHANG Xiang-feng
Department of Cardiology, Shanghai Corps Hospital, Chinese People’s Armed Police Forces, Shanghai 201103, China
关键词:
冠状动脉疾病; 支架; CD40配体; 基质金属蛋白酶
Keywords:
coronary disease;  stents;  CD40L;  matrix metalloproteinases
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 观察CD40L和基质金属蛋白酶（MMPs）与冠脉支架介入治疗术后冠状动脉再狭窄的关系，并分析CD40L和MMPs检测的临床意义。方法: 选择330例行冠脉支架置入术冠心病患者。对所有患者分别于术前，术后1个月，6个月，1年，采用ELISA法测定CD40L、C反应蛋白（CRP）、MMP-2、MMP-9。按照冠状动脉狭窄评分（CSA），再将32例支架术后再狭窄患者分为Ⅰ、Ⅱ、Ⅲ 3组。结果: 冠状动脉狭窄患者术后1个月，6个月，1年CD40L、CRP， MMP-2、MMP-9等较术前均有显著降低，术后再狭窄患者上述指标增高明显，随病情加重而升高，CSA积分越高上述指标增高越明显。MMP-2、MMP-9与CD40L呈正相关性（分别为r=0.51，r=0.64）。结论: CD40L和MMPs与支架术后冠状动脉再狭窄形成有一定的相关性，CD40L和MMPs的检测，有助于冠脉支架术后临床疗效的评价。
Abstract:
AIM: To study the effect of CD40L and matrix metalloproteinases on coronary artery restenosis after coronary artery stent interpolation (CASI) and to evaluate the prognosis of CASI by measuring the hematology level of CD40L and matrix metalloproteinases. METHODS: Three hundred and thirty patients with coronary artery disease received CASI, 186 were male and 144 female (average age was 69.4 years). Hematology levels of CD40L, CRP, MMP-2 and MMP-9 of all 330 patients were measured by enzyme-linked immunosorbent assay (ELISA), respectively, before and 1 and 6 months as well as 1 year after CASI. According to CSA criteria, 32 cases of coronary artery restenosis after CASI were classified into group one, group two and group three. RESULTS: Compared with the values before the interventional therapy, hematology levels of CD40L, CRP, MMP-2 and MMP-9 among the selected patients, without exception, decreased significantly 1 month, 6 months and 1 year after CASI. In the cases of post-CASI coronary artery restenosis, the previously mentioned corresponding items increased evidently, and the values were positively correlated with CSA grade and severity of CAD. CONCLUSION: CD40L and MMPs are related to coronary artery restenosis after CASI. CD40L may injure the coronary artery a second time through MMPs and thus result in the formation of atheromatous plaques. The measurement of hematology levels of CD40L and MMPs are of some value in predicting the prognosis of CASI.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-11-3.作者简介：张庆成，副主任医师，博士Email：wongli-0806@Sino.com
更新日期/Last Update: 2009-09-30