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参考文献/References

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［2］ Zhu X, Cao Y, Voogd K, et al. On the processing of proghrelin to ghrelin［J］. J Biol Chem, 2006, 281(50):38867-38870.

［3］ Guo ZF, Zheng X, Qin YW, et al. Circulating preprandial ghrelin to obestatin ratio is increased in human obesity［J］. J Clin Endocrinol Metab, 2007, 92(5):1875-1880.

［4］ Nakahara T, Harada T, Yasuhara D, et al. Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa［J］. Biol Psychiatry, 2008, 64(3):252-255.

［5］ Fontenot E, DeVente JE, Seidel ER. Obestatin and ghrelin in obese and in pregnant women［J］. Peptides, 2007, 28(10):1937-1944.

［6］ Vicennati V, Genghini S, De Iasio R, et al. Circulating obestatin levels and the ghrelin/obestatin ratio in obese women［J］. Eur J Endocrinol, 2007, 157(3):295-301.

［7］ Huda MS, Durham BH, Wong SP, et al. Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal［J］. Int J Obes (Lond), 2008, 32(1):129-135.

［8］ Chanoine JP, Wong AC, Barrios V, et al. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas［J］. Horm Res, 2006, 66(2):81-88.

［9］ Qi X, Li L, Yang G, et al. Circulating obestatin levels in normal subjects and in patients with impaired glucose regulation and type 2 diabetes mellitus［J］. Clin Endocrinol (Oxf), 2007, 66(4):593-597.

［10］Catalan V, Gomez-Ambrosi J, Rotellar F, et al. The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus［J］. Clin Endocrinol (Oxf), 2007, 66(4):598-601.

［11］Green BD, Irwin N, Flatt PR. Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice［J］. Peptides, 2007, 28(5):981-987.

［12］Anderwald-Stadler M, Krebs M, Promintzer M, et al. Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans［J］. Am J Physiol Endocrinol Metab, 2007, 293(5):E1393-E1398.［13］Li WG, Gavrila D, Liu X, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells［J］. Circulation, 2004, 109(18):2221-2226.

［14］Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells［J］. J Clin Invest, 2004, 114(1):57-66.

［15］Zhao D, Zhan Y, Zeng H, et al. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells［J］. J Cell Biochem, 2006, 97(6):1317-1327.

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［20］Kotani K, Sakane N, Saiga K, et al. Serum ghrelin and carotid atherosclerosis in older Japanese people with metabolic syndrome［J］. Arch Med Res, 2006, 37(7):903-906.

［21］Poykko SM, Kellokoski E, Ukkola O, et al. Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males［J］. J Intern Med, 2006, 260(1):43-52.

［22］Iglesias MJ, Salgado A, Pieiro R, et al. Lack of effect of the ghrelin gene-derived peptide obestatin on cardiomyocyte viability and metabolism［J］. J Endocrinol Invest, 2007, 30(6):470-476.

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Ghrelin/obestatin系统与心血管疾病研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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