视黄酸信号与胚胎心脏发育的关系
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2010年第1期
- 页码:
- 130-132
- 栏目:
- 综述
- 出版日期:
- 2010-01-04
文章信息/Info
- Title:
- -
- Author(s):
- -
- Keywords:
- -
- 分类号:
- R977.21
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 视黄酸(RA)是维生素A的代谢产物，在胚胎发育中起着重要的作用，对RA信号的研究已经成为发育生物学研究领域的热点之一。心脏发育过程中，主要包括：心脏原基的出现、心管形成、左右不对称发育、心脏环化、腔室形成、内流系统形成及传导系统发生等阶段。本文从心脏不同发育阶段着手，综述了国内外对RA信号影响心脏发育的最新研究进展，为先天性心脏病的防治提供线索。
- Abstract:
- -
参考文献/References
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［3］ Collop AH, Broomfield JA, Chandraratna RA, et al. Retinoic acid signaling is essential for formation of the heart tube in Xenopus［J］. Dev Biol, 2006, 291(1):96-109.
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［5］ 张立凤，桂永浩，钟涛，等. 视黄酸影响斑马鱼胚胎心脏房室分化［J］. 复旦学报， 2007, 34 (1):88-91.
［6］ Smith TK, Bader DM. Signals from both sides: Control of cardiac development by the endocardium and epicardium［J］. Semin Cell Dev Biol, 2007, 18(1):84-89.
［7］ Ren X, Li Y, Ma X, et al. Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts［J］. Life Sci, 2007, 81(2):89-96.
［8］ Palm-Leis A, Singh US, Herbelin BS, et al. Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes［J］. J Biol Chem, 2004, 279(52):54905-54917.
［9］ Yokoyama U, Sato Y, Akaike T, et al. Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus［J］. Physiol Genomics, 2007, 31(1):139-157.
［10］Cipollone D, Amati F, Carsetti R, et al. A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice［J］. Cardiovasc Pathol, 2006, 15(4):194-202.
［11］Ratajska A, Zotorowicz R, Bazejczyk M, et al. Coronary artery embryogenesis in cardiac defects induced by retinoic acid in mice［J］. Birth Defects Res A Clin Mol Teratol, 2005, 73(12):966-979.
备注/Memo
- 备注/Memo:
- 收稿日期：2008-1-7.基金项目：南京市医学科技发展重点项目资助(ZKX05009)； 江苏省科技厅项目资助(BS2005607) 通讯作者：王大为，教授，主要从事心血管疾病的研究Email：Wangdawei1947@yahoo.com.cn 作者简介：龚春华，主治医师，硕士Email：gongch@nicemice.cn
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