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|本期目录/Table of Contents|

新型肺动脉带瓣管道移植动物实验与血流动力学评价

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
180-182
栏目:
基础研究
出版日期:
2010-03-04

文章信息/Info

Title:
Animal experiments of valve replacement with bioprosthetic pulmonary valve conduit
作者:
李子林1; 2; 刘金成1; 段维勋1; 易定华1
1.第四军医大学西京医院心血管外科，陕西 西安 710032；2.解放军第452医院心胸外科，四川 成都 610061
Author(s):
LI Zi-lin1; 2;  LIU Jin-cheng1;  DUAN Wei-xun1;  YI Ding-hua1
1.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, Shaanxi, China; 2.Department of Cardiothoracic Surgery, PLA 452 Hospital, Chengdu 610061, Sichuan, China
关键词:
肺动脉带瓣管道; 肺动脉瓣; 犬; 移植; 血流动力学
Keywords:
bioprosthetic;  pulmonary valve conduit;  dog;  transplantation;  hemodynamics
分类号:
R617
DOI:
-
文献标识码:
A
摘要:
目的: 对我们与佰仁公司共同研制的肺动脉带瓣管道进行犬移植实验并进行血流动力学评价。方法: 肺动脉带瓣管道在体外循环辅助心脏不停跳下对犬行肺动脉瓣置换术,术后持续监测生命体征，术中及术后观察瓣膜血流动力学变化。结果: 8条犬6条存活，且存活均超过1个月,存活个体状态良好。死亡的犬中1条由于呼吸机故障，1条可能与瓣膜不匹配有关。手术前后无明显血流动力学变化，手术后右室-肺动脉无明显压差。结论: 新型改良肺动脉带瓣管道植入实验犬是适合的。新型肺动脉带瓣管道已显示出优良的血流动力学优势。
Abstract:
AIM: To assess hemodynamic performance of right ventricular outflow tract and pulmonary artery reconstruction (RV-PA) in dogs. METHODS: Eight adult dogs underwent implanted bioprosthetic pulmonary valved conduit in pulmonary position under cardiopulmonary bypass with beating heart. Right ventricular and pulmonary artery pressures were measured directly before and after implantation. RESULTS: Six adult dogs survived in good condition after surgery and survived 1 month after implantation. One dog died from mismatch of prosthetic valve at postoperative day 10. The other dog died due to respiratory failure . The mean gradient was not different significantly between discharge and the post-operation. CONCLUSION: The new bioprosthetic pulmonary valve conduit shows good performance in animal experiments and good short-term hemodynamic performance.

参考文献/References

［1］ Dearani JA, Danielson GK, Puga FJ, et al. Late follow-up of 1095 patients undergoing operation for complex congenital heart disease utilizing pulmonary ventricle to pulmonary artery conduits［J］. Ann Thorac Surg, 2003, 75(2):399-410.

［2］ Breymann T, Thies WR, Boethig D, et al. Bovine valved venous xenografts for RVOT reconstruction: results after 71 implantations［J］. Eur J Cardiothorac Surg, 2002, 21(4):703- 710.

［3］ Herijgers P, Ozaki S,Verbeken E, et al. Valved jugular vein segments for right ventricular outflow tract reconstruction in young sheep［J］. J Cardiovasc Surg, 2002,124(4):798-805.

［4］ Carrel T, Berdat P, Pavlovic M, et al. The bovine jugular vein: a totally integrated valved conduit to repair the right ventricular outflow ［J］. J Heart Valve Dis, 2002, 11(4) :552-556.

［5］ Corno AF, Hurni M, Griffin H, et al. Bovine jugular vein as right ventricle-to-pulmonary artery valved conduit［J］. J Heart Dis, 2002, 11(2):242-247.

［6］ 高天舒,余坚,谷依学,等. 戊巴比妥钠联用速眠新在手术实验犬中的麻醉效果观察［J］. 南华大学学报(医学版), 2005, 33(4):505-507.

［7］ 袁义,王武军,蔡开灿,等. 绵羊二尖瓣置换动物模型的制作［J］. 中国组织工程研究与临床康复, 2007, 11(21):4097-4100.

备注/Memo

备注/Memo:
收稿日期：2009-3-9.基金项目：国家863科技计划攻关重大课题（2006AA02A138）资助 通讯作者：易定华，主任医师，教授，主要从事心脏移植及心肺联合移植的研究Email:yidh@fmmu.edu.cn 作者简介：李子林，硕士生Email:lizilin98@fmmu.edu.cn
更新日期/Last Update: 2010-03-05