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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2010年第3期

页码:

373-375

栏目:

临床研究

出版日期:

2010-04-06

文章信息/Info

Title:

Association between elderly hypertensive subjects and nonalcoholic fatty liver

作者:

马丽娜¹; 冯明¹; 马佳²; 周英智¹; 黄萍¹

首都医科大学宣武医院：1.综合科，2.超声诊断科，北京 100053

Author(s):

MA Li-na¹;  FENG Ming¹;  MA Jia²;  ZHOU Ying-zhi¹;  HUANG Ping¹

1.Integrated Department, 2.Department of Ultrasound Diagnosis, Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China

关键词:

高血压; 原发性; 非酒精性脂肪肝; 老年人

Keywords:

hypertension;  nonalcoholic fatty liver;  elderly patients

分类号:

R544.1

DOI:

-

文献标识码:

A

摘要:

目的: 探讨老年原发性高血压(EH)并发非酒精性脂肪肝(NAFLD)的相关影响因素。方法: 将90例老年高血压病患者分成2组，NAFLD组40例，非NAFLD组50例，比较两组间体质量指数（BMI）、腰臀比（WHR）、总胆固醇（TC）、三酰甘油（TG）、C反应蛋白（CRP）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、血肌酐（Cr）和空腹血糖（FPG）的差异，并进行Logistic回归分析。结果: NAFLD组与非NAFLD组在BMI（26.8±2.3与22.6±2.4，P<0.01）、WHR（0.96±0.03与0.91±0.04，P<0.01）、TG［（2.6±0.4）mmol/L与(2.0±0.5)mmol/L，P<0.01］、HDL-C［（1.5±0.3）mmol/L与(1.7±0.4)mmol/L，P<0.01］、ALT［（31±8）mmol/L与(26±7)mmol/L，P<0.05］、AST［（28±7）mmol/L与(24±7)mmol/L，P<0.05］、FPG［（5.2±0.8）mmol/L与(4.8±0.7)mmol/L，P<0.01］的差异有统计学意义，Logistic回归分析显示BMI（P<0.01）、WHR（P<0.01）和TG（P<0.01）是高血压病并发NAFLD的独立影响因素。结论: BMI、WHR和TG是高血压并发NAFLD的独立危险因素。

Abstract:

AIM: To explore the associated factors between essential hypertension (EH) and nonalcoholic fatty liver (NAFLD) in elderly patients. METHODS: Ninety elderly hypertensive patients were divided into two groups: EH co-existing with NAFLD group (n=40) and group of patients with EH without NAFLD (n=50). Body mass index (BMI), waist/hip ratio (WHR), total cholesterol (TC), triglycerides (TG), C-reactive protein (CRP), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (Cr) and fasting plasma glucose (FPG) were compared between groups and logistic regression was analyzed. RESULTS: In the group of EH co-existing with NAFLD, levels of BMI (26.8±2.3 vs.22.6±2.4, P<0.01), WHR (0.96±0.03 vs. 0.91±0.04, P<0.01), TG ［(2.6±0.4) mmol/L vs.(2.0±0.5) mmol/L, P<0.01］, ALT ［(31±8) mmol/L vs.(26±7) mmol/L, P<0.05］, AST ［(28±7) mmol/L vs.(24±7) mmol/L, P<0.05］, and FPG ［(5.2±0.8) mmol/L vs.(4.8±0.7) mmol/L, P<0.01］ were higher than in the EH without NAFLD group, whereas HDL-C ［(1.5±0.3) mmol/L vs.(1.7±0.4) mmol/L, P<0.01］ was lower than in the EH without NAFLD group. Logistic regression showed that BMI (P<0.01), WHR (P<0.01) and TG (P<0.01) were independent factors. CONCLUSION: BMI, WHR and TG are independent factors of EH co-existing with NAFLD in elderly patients.

参考文献/References

［1］中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪肝病诊疗指南［J］. 中华肝脏杂志， 2006，14（3）：161-163.

［2］ Bedogni G, Bellentani S. Fatty liver, how frequent is it and why［J］. Ann Hepatol, 2004, 3(2)：63-65.

［3］ Donati G, Stagni B, Piscagli F, et al. Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance［J］. Gut, 2004, 53(7)：1020-1023.

［4］ Fan JG, Zhu J, Li XJ, et al. Prevalence of and risk favtors for liver in a general population of shanghai, China［J］. J Hepatol, 2005, 43(3)：508-514.

［5］ Methta K, van Thiel DH, Shah N, et al. Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants［J］. Nutr Rev, 2002, 60(9)：289-293.

［6］何淑梅，孔俭，牛俊奇. 非酒精性脂肪性肝病研究现状及进展［J］.中国老年学杂志， 2008， 28(4):725-727.

［7］ 展玉涛. 非酒精性脂肪肝与心血管疾病［J］. 中华内科杂志， 2007， 46(10)：868-869.

［8］ 徐新娟，胡广梅，王明建，等. 高血压合并非酒精性脂肪肝的临床特点［J］. 中华高血压杂志， 2008, 16(11)：979-983.

［9］Santoliquido A, Di Campli C, Miele L, et al. Hepatic steatosis and vascular disease［J］. Eur Rev Med Pharmacol Sci, 2005, 9(5)：269-271.

［10］Videla LA, Rodrigo R, Araya J, et al. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease［J］. Trends Mol Med, 2006, 12(12)：555-558.

备注/Memo

备注/Memo:

收稿日期：2008-11-24.作者简介：马丽娜，医师，硕士Email:malina0883@yahoo.com.cn

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更新日期/Last Update: 2010-04-09