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|本期目录/Table of Contents|

LP-PLA2与冠状动脉粥样硬化性心脏病的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第3期
页码:
444-446
栏目:
综述
出版日期:
2010-04-06

文章信息/Info

Title:
-
作者:
陈锦峰徐新
汕头大学医学院附属粤北人民医院心内科,广东 韶关 512026
Author(s):
-
关键词:
脂蛋白相关磷脂酶A2冠状动脉粥样硬化冠状动脉疾病
Keywords:
-
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
近年研究发现,脂蛋白相关磷脂酶A2(Lp-PLA2)是不同于白细胞介素、细胞间黏附分子和高敏C反应蛋白 (hs-CRP)等传统冠心病危险因子,成为冠心病新的预测因子,并指出其与动脉粥样硬化性病变及斑块稳定密切相关。
Abstract:
-

参考文献/References

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[2]Corsetti JP, Rainwater DL, Moss AJ, et al. High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients[J]. Clin Chem, 2006, 52(7):1331-1338.

[3] 李巧汶,邱健. 炎症标记物与冠心病关系的研究进展[J]. 心脏杂志, 2008, 20(3):359-362.

[4]朱毓,吴美华. 脂蛋白相关磷脂酶A2与动脉粥样硬化性疾病[J]. 心脏杂志, 2008, 20(1):101-103.

[5] Brilakis ES, McConnell JP, Lennon RJ , et al. Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angio-graphic coronary artery disease, and major adverse events at follow-up[J] . Eur Heart J, 2005, 26(2):137-144.

[6] Pión P, Kaski JC. Inflammation, atherosclerosis and cardiovascular disease risk: PAPP-A, Lp-PLA2 and cystatin C. New insights or redundant information?[J]. Rev Esp Cardiol, 2006, 59(3):247- 258.

[7]Sudhir K. Clinical review: Lipoprotein-asso-ciated phospholipase A2, a novel inflammatory biomarker and independent risk predictorfor cardiovascular disease[J] . J Clin Endocrinol Metab, 2005, 90(5):3100-3105.

[8] Yang EH, McConnell JP, Lennon RJ, et al. Lipoprotein-associated phospholipase A2 is an independent marker for coronary endothelial dysfunction in humans[J]. Arterioscler Thromb Vasc Biol, 2006, 26(1):106-111.

[9] Iribarren C, Gross MD, Darbinian JA, et al. Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults: the CARDIA study[J]. Arterioscler Thromb Vasc Biol, 2005, 25(1):216-221.

[10]Oei HH, van der Meer IM, Hofman A, et al. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study[J]. Circulation, 2005, 111(5):570-575.

[11]Kolodgie FD, Burke AP, Skorija KS, et al. Lipoprotein-associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis[J]. Arterioscler Thromb Vasc Biol, 2006, 26(11):2523-2529.

[12]Wilensky RL, Shi Y, Mohler ER, et al. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development[J]. Nat Med, 2008, 14(10):1015-1016.

[13]Anderson JL. Lipoprotein-associated phosp holipase A2: an independent predictor of coronary artery disease events in primary and secondary prevention[J]. Am J Cardiol, 2008, 101(12A):23F-33F.

[14]Koenig W, Twardella D, Brenner H, et al. Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress[J]. Arterioscler Thromb Vasc Biol, 2006, 26(7):1586-1593.

[15]ODonoghue M, Morrow DA, Sabatine MS, et al. Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) trial[J]. Circulation, 2006, 113(14):1745-1752.

[16]Winkler K, Winkelmann BR, Scharnagl H, et al. Platelet-activating factor acetylhydrolase activity indicates angiographic coronary artery disease independently of systemic inflammation and other risk factors: the Ludwigshafen Risk and Cardiovascular Health Study[J]. Circulation, 2005, 111(8):980-987.

备注/Memo

备注/Memo:
收稿日期:2009-07-14.通讯作者:徐新,主任医师,主要从事冠心病介入诊疗研究 Email:03xuxin@163.com 作者简介:陈锦峰,硕士生Email:zhangshebing618@163.com
更新日期/Last Update: 2010-04-09