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酪醇半乳糖苷的合成及对缺血/再灌注心脑的保护作用研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
524-528
栏目:
基础研究
出版日期:
2010-06-10

文章信息/Info

Title:
Synthesis of tyrosol galactoside and its protective effects on heart and brain with ischemia/reperfusion injuries
作者:
石天尧1; 冯书芳2; 袁立邦2; 刘雪英1; 孙晓莉1
第四军医大学:1.药学系化学教研室,2.西京医院麻醉科,陕西 西安 710032
Author(s):
SHI Tian-yao1;  FENG Shu-fang2;  YUAN Li-bang2;  LIU Xue-ying1;  SUN Xiao-li1
1.Department of Chemistry, School of Pharmacy, 2.Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
酪醇半乳糖苷; 红景天苷; 缺血再灌注损伤
Keywords:
tyrosol galactoside;  salidroside;  ischemia-reperfusion injury
分类号:
R962
DOI:
-
文献标识码:
A
摘要:
目的: 设计合成一种新的红景天苷(salidroside，SDS)类似物—酪醇半乳糖苷(tyrosol galactoside，TG)，进一步探讨其对心脑的保护作用并与红景天苷的保护作用进行比较。方法： 实验分为两个部分：分别采用大鼠大脑中动脉闭塞(MCAO)模型和大鼠心肌缺血/再灌注(I/R)模型，通过神经功能评分(NBS)和TTC染色，评价两者(SDS和TG)的脑保护功能。通过左室收缩压（LVSP）、左室等容收缩/舒张期压力上升或下降最大速率(±dp/dtmax)、血清中肌酸激酶(CK)的活性和丙二醛(MDA)的水平评价两者的心脏保护功能。结果： TG和SDS均能显著改善大鼠局灶性脑I/R损伤NBS，减少脑梗死容积，但二者无统计学差异。与SDS相比较，TG组的LVSP和±dp/dtmax显著提高(P<0.05)，血清中CK的活性和MDA的浓度也显著降低（P<0.01）。结论： TG和SDS均具有明显的心脑保护作用，但前者的心肌保护作用强于后者。
Abstract:
AIM: To design and synthesize a new analogue of salidroside-tyrosol galactoside, observe its protective effects on focal cerebral and cardiac ischemia/reperfusion (I/R) injuries and compare its protective effects with those of salidroside. METHODS: Using the model of middle cerebral artery occlusion (MCAO), we evaluated functions of cerebral protection by neurological behavior score (NBS) and TTC staining. In the model of myocardial I/R, left ventricular systolic pressure (LVSP) and maximal first derivative of developed pressure (±dP/dtmax) were monitored throughout the experiments. Serum creatine kinase (CK) and malondialdehyde (MDA) were detected at the end of reperfusion for evaluation of cardiac protection. RESULTS: Tyrosol galactoside and salidroside significantly improved NBS and reduced cerebral infarction volume with no statistical difference. In myocardial protection, tyrosol galactoside significantly increased LVSP and (±dP/dtmax) and decreased activities of CK. Level of MDAI and its protective effect was stronger than that of salidroside. CONCLUSION: Tyrosol galactoside and salidroside both have obvious protective effects on heart and brain. However, compared with salidroside, tyrosol galactoside has stronger effects on myocardial protection.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-12-23.通讯作者：孙晓莉，教授，主要从事心脑血管药物的研究 Email:lisydcn@yahoo.com.cn 作者简介：石天尧，硕士生Email:jerry11@fmmu.edu.cn
更新日期/Last Update: 2010-05-20