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|本期目录/Table of Contents|

高龄老年患者原发性高血压分期和血压控制效果与血管活性物质和血脂水平的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
551-553
栏目:
临床研究
出版日期:
2010-06-10

文章信息/Info

Title:
Effect of stages of essential hypertension and blood pressure control on endovascular active substance and blood lipid level in elderly subjects
作者:
倪宁1; 莫晓燕2; 于德兰1; 王海昌3
西安交通大学：1.医院内科，2.生命科学与技术学院生物工程系，陕西 西安710049；3.第四军医大学西京医院心脏内科，陕西 西安710032
Author(s):
NI Ning1;  MO Xiao-yan2;  YU De-lan1;  WANG Hai-chang3
1.Department of Internal Medicine, Hospital of Xian Jiaotong University, 2.Department of Biology Engineering, Institute of Life Sciences and Technology, Xian Jiaotong University, Xi’an 710049, Shaanxi, China; 3.Department of Cardiology, Xijing Hospital, F
关键词:
血管活性物质; 高血压; 原发性; 高龄老年人; 血脂
Keywords:
endovascular active substance;  essential hypertension;  elderly subjects;  blood lipids
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的: 观察和分析高龄老年患者原发性高血压（EH）分期和不同控制状态与血浆血管活性物质及血脂水平的关系。方法: 80岁以上离退休人员60例为研究对象，分为Ⅰ，Ⅱ，Ⅲ期，血压控制理想组与不理想组。应用放射免疫法测定血浆肾上腺髓质素（ADM）、内皮素（ET）、心房钠尿肽（ANP）和血管紧张素Ⅱ（AngⅡ）的水平，硝酸还原酶法测定NO。血脂采用酶试剂法，免疫浊度法。结果: EHⅠ期AngⅡ显著升高，EHⅡ期ADM,ET,ANP显著升高，NO显著降低。EHⅢ期ADM,ET,ANP,AngⅡ较Ⅱ期显著升高，NO较Ⅰ，Ⅱ期显著降低。理想组NO,ANP,AngⅡ较对照组无显著差异，理想组较不理想组ADM,NO,ET,ANP有显著差异。血脂指标在各组间无显著差异。结论: 血管活性物质的水平可作为临床分期与评价治疗效果的指标之一。
Abstract:
AIM: To observe and analyze the effect of essential hypertension (EH) stages and results of blood pressure control on endovascular active substance and blood-lipid level in seniors. METHODS: Sixty elderly, retired subjects aged >80 years were divided into five groups: I-period group, II-period group, III-period group, ideal blood pressure control group and non-ideal blood pressure control group. Radioimmunization was used to measure levels of ADM, ET, ANP and AngII, and nitric acid reductase was used to measure NO. Blood lipid level was tested enzymatically method and with the turbidimetric immunoassay method. RESULTS: AngII of EH I period rose significantly. ADM, ET and ANP of EH II period rose but NO dropped significantly. ADM, ET, ANP, AngII of EH III period rose significantly compared with those of EH II period. NO of EH III period decreased significantly compared with that of I and II periods. NO, ANP and AngII of ideal blood pressure control group were not significantly different from those in the control group, but ADM, NO, ET and ANP in the ideal group were significantly different from those in the non-ideal blood pressure control group. No significant difference was found in blood lipid levels among all groups. CONCLUSION: The level of endovascular active substance can be used as one of the indices to establish clinical stages and evaluate curative effects.

参考文献/References

［1］曹剑,李小鹰. 血管内皮功能研究现状［J］. 中华老年心脑血管病杂志, 2002, 4(3)206-208.

［2］ 倪宁,王建智,巨安丽,等. 原发性高血压不同危险度分层中血管活性物质的水平及药物治疗的影响［J］. 心脏杂志, 2005, 17(6):536-538.

［3］Withers DJ, Coppock HA, Seufferlein T, et al. Adrenomedullin stimulates DNA synthesis and cell proliferasion via elevation of cAMP in Swiss 3T3 cells［J］. FEBS Lett, 1996, 378(1):83-87.

［4］Kitamura K, Sakata J, Kangawa K, et al. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin［J］. Biochem Biophys Res Commun, 1993, 194(2):720-725.

备注/Memo

备注/Memo:
收稿日期：2009-03-31.作者简介：倪宁，主治医师，硕士Email:stpuma63@163.com
更新日期/Last Update: 2010-05-20