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|本期目录/Table of Contents|

冠状动脉钙化患者的血浆BMP-2水平及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
584-585,594
栏目:
临床研究
出版日期:
2010-06-10

文章信息/Info

Title:
Plasma BMP-2 level and its clinical significance in patients with coronary calcification
作者:
张铭; 李志忠; 李爱军; 张京梅; 王苏; 陶英; 马长生
首都医科大学附属北京安贞医院心内科、北京市心肺血管研究所，北京 100029
Author(s):
ZHANG Ming;  LI Zhi-zhong;  LI Ai-jun;  ZHANG Jing-mei;  WANG Su;  TAO Ying;  MA Chang-sheng
Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China
关键词:
骨形态发生蛋白; 冠状动脉钙化
Keywords:
bone morphogenetic protein-2;  coronary calcification
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
目的: 研究冠状动脉钙化患者血浆骨形态发生蛋白-2（BMP-2）的水平及临床意义。方法: 根据冠状动脉造影(CAG)结果将171例患者分3组：正常对照组、冠状动脉狭窄无钙化组，冠状动脉狭窄伴钙化组，比较3组患者BMP-2水平的差异。结果: CAG发现有冠状动脉钙化的患者组BMP-2水平高于正常组及冠状动脉狭窄而无钙化组。结论: BMP-2水平升高可能是动脉钙化标志之一。
Abstract:
AIM: To investigate plasma BMP-2 level and its clinical significance in patients with coronary calcification. METHODS: According to the results of coronary angiography (CAG), 171 patients were divided into three groups: control group, stenosis without coronary calcification group, and stenosis with coronary calcification group. Plasma BMP-2 levels were studied and the plasma concentrations of BMP-2 were measured by enzyme-linked immunosorbent assays (ELISA). RESULTS: Plasma BMP-2 levels in stenosis with coronary calcification group were higher than in the group of stenosis without coronary calcification. CONCLUSION: Elevation of plasma BMP-2 levels can be used as a marker for detection of coronary calcification.

参考文献/References

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[6]Khurana C, Rosenbaum CG, Howard BV, et al. Coronary artery calcification in black women and white women［J］. Am Heart J,2003, 145(4):724-729.

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备注/Memo

备注/Memo:
收稿日期：2009-08-15.作者简介：张铭 ，主治医师，博士Email:mingzhang2003@yahoo.com.cn
更新日期/Last Update: 2010-05-20