低声压级水平次声对心肌梗死大鼠心肌纤维化的影响及机制研究
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2010年第6期
- 页码:
- 852-855
- 栏目:
- 基础研究
- 出版日期:
- 2010-08-23
文章信息/Info
- Title:
- Effects of low-decibel infrasound on cardiac fibrosis of rats with acute myocardial infarction and underlying mechanism
- 作者:
- 吴敬国1; 梁艳冰1; 唐皓1; 裴兆辉2; 庄志强3; 马虹2; 马中富1
- 中山大学附属第一医院：1.普内科，2.心内科，广东 广州 510080；3.中山大学附属第二医院康复科，广东 广州 510120
- Author(s):
- WU Jing-guo1; LIANG Yan-bing1; TANG Hao1; PEI Zhao-hui2; ZHUANG Zhi-qiang3; MA Hong2; MA Zhong-fu1
- 1.Department of Internal Medicine, 2.Department of Cardiology, First Affiliated Hospital, SUN YAT-Sen University, Guangzhou 510080, Guangdong, China; 3.Department of Physical Therapy and Rehabilitation, Second Affiliated Hospital, SUN YAT-Sen University, Guangzhou 510120, Guangdong, China
- Keywords:
- infrasound; rat; cardiac fibrosis; myocardial infarction
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的: 观察次声对心肌梗死后大鼠心肌纤维化的影响及相关机制研究。方法: 将30只SD大鼠随机分为3组，即假手术组、心肌梗死组及次声治疗组，每组10只。采用低声压级水平次声对心肌梗死大鼠治疗1周（2次/d，0.5 h/次）， 观察心肌胶原和血浆NO和血管紧张素-Ⅱ（AngⅡ）及大鼠心功能的变化。结果: 与心肌梗死组大鼠比较（未治疗组），次声治疗组大鼠心肌胶原表达明显减少，血浆NO含量显著增加（P<0.01），血浆AngⅡ含量显著降低（P<0.01），心功能明显改善（P<0.01）。结论: 低声压级水平次声治疗能够明显减轻心肌梗死后大鼠心肌纤维化，其作用可能与血浆NO及AngⅡ含量变化有关。
- Abstract:
- AIM: To observe the changes of cardiac fibrosis and its underlying mechanism after acute myocardial infarction in rats. METHODS: Thirty male Sprague Dawley rats were randomized to control group, infarction group and infrasound treatment group (10 rats/group). Rats in the infrasound treatment group were treated with infrasound for 7 days, 0.5 h, twice/day. Collagen expression of rat myocardium and contents of NO and Ang-II in rat plasma and rat heart function were observed. RESULTS: Compared with those in the infarction group, the collagen expression of rat myocardium increased in the infrasound treatment group (P<0.01), the contents of NO in rat plasma significantly decreased (P<0.01), the contents of ET-1 in rat plasma significantly increased (P<0.01), and heart function was significantly improved. CONCLUSION: Infrasound treatment significantly assuages the cardiac fibrosis of rats after myocardial infarction, which may be relative with the changes of NO and Ang-II.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2009-08-21.基金项目：中国博士后科学基金资助(20081266)；国家自然科学基金项目资助（30870579） 通讯作者：马中富，主任医师，主要从事内科基础及临床研究Email：ma＿zf@pom.com 共同通讯作者：裴兆辉，副教授，主要从事次声生物学效应研究Email：leak123@126.com 作者简介：吴敬国，医师，博士Email:leak123@sina.com.cn
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