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Title:: Study on serum interleukin-1β level in depressed patients with coronary heart disease

作者:: 帕丽达·阿布来提¹; 库木斯²; 古丽扎尔·买买提明¹; 新疆医科大学第一附属医院：1.干部心血管二科;2.心身科,新疆乌鲁木齐 830054

Author(s):: PA Li-da1; KU Musi2; GU Li Zaer3; 1.Second Department of Cardiology, 2.Department of Psychosomatics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China

关键词:: 冠状动脉疾病; 抑郁; 白细胞介素-1β

Keywords:: coronary disease; depression; interleukin-1β

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的: 研究抑郁对冠心病稳定型心绞痛患者血清白介素-1β（IL-1β）水平的影响。方法: 收集2007年7月~12月住院治疗年龄≥50岁的冠心病稳定型心绞痛患者86例。根据ZUNG抑郁自评量表（SDS）评定标准分组，即冠心病伴抑郁患者62例，冠心病不伴抑郁患者24例，对两组患者的临床特征，血脂、血糖及IL-1β检测结果进行对比分析。结果: 两组患者在年龄、性别构成、吸烟、饮酒、受教育程度、并发高血压病、糖尿病等之间的差异无统计学意义。冠心病伴抑郁组IL-1β水平显著高于冠心病不伴抑郁组（P<0.05）。SDS问卷积分与IL-1β呈正相关（r=0.30，P<0.01）。同时按轻、中、重程度与IL-1β相关分析也呈正相关（r=0.35，P<0.05）。两组患者血脂水平无显著性差异，且与IL-1β之间没有相关性。结论: 冠心病稳定型心绞痛患者抑郁与血清IL-1β水平相关。

Abstract:: AIM: To investigate the influence of depression on the serum interleukin-1β level of patients with coronary heart disease (CAD) with stable angina pectoris (SAP). METHODS: Eighty-six patients (age≥50 years) with CAD with SAP admitted to our department from August 2007 to December 2007 were divided into two groups by ZHUG questionnaire (SDS) scores: Group A (patients with depression, n=62) and Group B (patients without depression, n=24). We analyzed the clinical data, serum lipids, blood glucose and interleukin-1β level of all patients in the two groups. RESULTS: No significant difference was found in age, gender, smoking, alcohol use, educational level, complications of hypertension, and complications of diabetes. The level of interleukin-1β in patients with CHD accompanied by depression was significantly higher than in patients with CHD without depression (P<0.05). Correlation analysis results showed that the SDS score was positively related to the level of interleukin-1β (r=0.35, P<0.05). No significant difference was observed in lipid level between groups and no correlation was found with interleukin-1β level. CONCLUSION: The level of interleukin-1β was positively related in CHD patients with SAP accompanied by depression.

参考文献/References

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冠心病稳定型心绞痛患者抑郁与血清白介素-1β水平相关

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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