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|本期目录/Table of Contents|

主动脉瓣钙化与冠心病有关联

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第6期
页码:
922-924
栏目:
临床研究
出版日期:
2010-08-23

文章信息/Info

Title:
Association between aortic valve calcification and coronary artery disease
作者:
龚东1; 楼建英2; 彭健1; 张伟2; 王达理2; 钱维源2
1.中山大学附属第五医院心内二科，广东 珠海 519000；2.解放军第四五四医院心内科，江苏 南京 210002
Author(s):
GONG Dong1;  LOU Jian-ying2;  PENG Jian1;  ZHANG Wei2;  WANG Da-li2;  QIAN Wei-yuan2
1.Department of Cardiology, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, Guangdong, China; 2.Department of Cardiology, PLA 454 Hospital, Nanjing 210002, Jiangsu, China
关键词:
主动脉瓣钙化; 冠状动脉疾病; 动脉粥样硬化; 超声心动描记术; 冠状动脉造影术
Keywords:
aortic valve calcification;  coronary artery disease;  atherosclerosis;  echocardiography;  coronary angiography
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨中国南方部分汉族人群主动脉瓣钙化与冠心病之间的关系。方法： 选取同期行冠状动脉造影检查和超声心动图检查患者1 153例，探讨主动脉瓣钙化与冠心病的相关性。结果： 冠心病组主动脉瓣钙化的检出率明显高于非冠心病组（32.6% vs. 13.9%,P<0.01），多因素Logistic回归分析结果显示，除传统危险因素如年龄、性别、高脂血症、糖尿病外，主动脉瓣钙化也是全组冠心病的一项独立的预测因子(OR=1.53，P<0.05)。结论： 主动脉瓣钙化与全组冠心病发病之间存在显著的相关性，是冠心病的一项有意义的独立预测因子。
Abstract:
AIM: To determine the relationship between aortic valve calcification (AVC) and coronary artery disease (CAD) in part of the Han population in southern China. METHODS: Enrolled in the study were 1 153 subjects who underwent both transthoracic echocardiography (TTE) and coronary arteriography (CAG), and the relationship between aortic valve calcification (AVC) and CAD was explored. RESULTS: The prevalence of AVC was significantly higher in the CAD group compared with that in non-CAD group (32.6% vs. 13.9%, P<0.01). Multiple logistic regression analysis showed that in addition to age, gender, diabetes mellitus and hyperlipidemia (all P<0.01), AVC (P<0.05) was an independent positive predictor of coronary arteriography. CONCLUSION: There is a significant association between the presence of AVC and CAD. Aortic valve calcification is an independent predictor of CAD.

参考文献/References

［1］Boon A, Cheriex E, Lodder J, et al. Cardiac valve calcification:characteristics of patients with calcification of the mitral annulus or aortic valve［J］. Heart, 1997, 78（5）:472-474.

［2］Scanlon PJ, Faxon DP, Audet AM, et al. ACC/AHA guidelines for coronary angiography. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines(Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac Angiography and Interventions［J］. J Am Coll Cardiol, 1999, 33（6）:1756-1824.

［3］Otto CM, Lind BK, Kitzman DW, et al. Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly［J］. New Engl J Med, 1999， 341（3）:142-147.

［4］Adler Y, Vaturi M, Herz I, et al. Nonobstructive aortic valve calcification: a window to significant coronary artery disease［J］. Atherosclerosis, 2002, 161（1）:193-197.

［5］Hisar I, Ileri IM, Yetkin E, et al. Aortic valve calcification: its significance and limitation as a marker for coronary artery disease［J］. Angiology, 2002, 53（2）:165-169.

［6］Cho Conte L, Rossi A, Cicoira M, et al. Aortic valve sclerosis: a marker of significant obstructive coronary artery disease in patients with chest pain?［J］. J Am Soc Echocardiogr, 2007, 20（6）:703-708.

［7］Acarturk E, Bozkurt A, Cayli M, et al. Mitral annular calcification and aortic valve calcification may help in predicting significant cor-onary artery disease［J］. Angiology, 2003, 54（5）:561-567.

备注/Memo

备注/Memo:
收稿日期：2009-09-17.通讯作者：楼建英，主任医师，主要从事心血管临床与心脏超声研究Email:ljy5528@sina.com 作者简介：龚东，医师，硕士Email:tjgd001@163.com
更新日期/Last Update: 2010-08-22