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|本期目录/Table of Contents|

microRNA-21及相关技术在心血管疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第2期
页码:
255-259，265
栏目:
综述
出版日期:
2010-12-10

文章信息/Info

Title:
-
作者:
苗裔 综述; 臧伟进 审校
西安交通大学医学院心血管生理药理研究室，陕西 西安710061
Author(s):
-
关键词:
microRNAs; microRNA-21; 心血管疾病
Keywords:
-
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
microRNAs（miRNAs）是近年发现的一类保守单链非编码RNA分子，由约19~24个核苷酸组成，在转录后水平调控基因的表达。miRNAs参与多种细胞进程，在疾病发生发展中也起重要作用。microRNA-21（miR-21）在多种类型肿瘤及心血管系统中均有表达，在心血管疾病的发生发展过程中发挥重要作用。本文从miRNAs的功能机制、研究方法，miR-21与心血管疾病的关系，靶基因预测及其表达干预手段等方面综述了miRNAs及miR-21现阶段的研究进展。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2010-07-10.基金项目：本研究工作受国家自然科学基金(重点项目No.30930105；面上项目No.30873058、30770785)，国家重点基础研究973发展计划(2007CB512005)和中华医学基金会杰出教授奖项目资助(F510000/G16916404) 通讯作者：臧伟进，教授，主要从事心血管生理药理学研究Email：zwj@mail.xjtu.edu.cn 作者简介：苗裔，博士生Email:miaoyi.xjtu@stu.xjtu.edu.cn
更新日期/Last Update: 2010-12-10