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中国北方汉族人群IL-18基因-607C/A和-137G/C多态与心肌梗死的关联性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第3期
页码:
331-335
栏目:
临床研究
出版日期:
2011-05-12

文章信息/Info

Title:
Association of interleukin-18 gene promoter polymorphisms with myocardial infarction in a Han population of northern China
作者:
张效林; 裴芳; 黄明方; 闫承慧; 康建; 梁振洋; 韩雅玲
沈阳军区总医院心内科，辽宁 沈阳 110016
Author(s):
ZHANG Xiao-lin;  PEI Fang;  HUANG Ming-fang;  YAN Cheng-hui;  KANG Jian;  LIANG Zhen-yang;  HAN Ya-ling
Department of Cardiology, Northern Hospital, Shenyang, Liaoning 110016, China
关键词:
冠状动脉疾病; 心肌梗死; 基因; 单核苷酸多态性
Keywords:
coronary disease;  myocardial infarction;  gene;  single nucleotide polymorphism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:近年研究发现白细胞介素-18（Interleukin18，IL-18)在冠心病(CAD)的发生、发展及粥样斑块破裂的过程中起重要作用。本研究探讨IL-18基因-607C/A和-137G/C单核苷酸多态与中国北方汉族人群心肌梗死(MI)的关系。方法： 采用序列特异性引物聚合酶链反应对432例对照组和468例MI患者进行检测，分析IL-18基因-607C/A和-137G/C单核苷酸多态的基因型和等位基因分布情况。结果: IL-18基因-607C/A单核苷酸多态3种基因型（CC型，CA型和AA型）在对照组分布频率分别为20.8 %，50.9 %和28.2 %，在MI组分别为36.3 %，44.9%和18.8%，IL-18基因-607C/A多态和中国北方汉族人群MI的发生显著相关(P<0.05)。IL-18基因-137G/C单核苷酸多态三种基因型（GG型，GC型和CC型）在对照组分布频率分别为71.3 %，26.8 %和1.9 %，在MI组分别为75.2 %，23.9 % 和0.9%，IL-18基因-137G/C单核苷酸多态与中国北方汉族人群MI无相关性(P=0.133)。两组间的基因型分布皆符合Hardy－Weinberg平衡定律。Logistic回归校正性别、年龄、体质量指数、吸烟、高血压病、高脂血症、糖尿病等CAD易患因素后，IL-18基因-607C/A多态仍是MI发病的独立的危险因素(P<0.05)。IL-18基因-607C/A和-137G/C单核苷酸多态组成的CG单体型与和MI的危险性呈正相关，而AC单体型与MI的危险性呈负相关。结论： IL-18基因-607C/A多态与中国北方汉族人群中与MI的发生独立相关。
Abstract:
AIM:To investigate the association between IL-18 promoter functional polymorphisms (-607C/A and -137G/C) and myocardial infarction (MI) in a Han population of northern China. METHODS: A case-control study was conducted in 468 patients with MI and 432 controls with normal results of coronary angiograms. Genotyping was performed by sequence-specific primer-polymerase chain reaction. RESULTS: Genotype frequencies of CC, CA and AA of the IL-18 -607C/A polymorphism were, respectively, 20.83%, 50.93% and 28.24% in the controls, and 36.32%, 44.87% and 18.81% in MI patients. Genotype frequencies of GG, GC and CC of the IL-18 -137G/C polymorphism were, respectively, 71.30%, 26.85% and 1.85% in controls and 75.21%, 23.93% and 0.86% in MI patients. Significant differences were observed in the genotype and allele distribution of -607C/A polymorphism of the IL-18 gene between cases and controls (P<0.05). Logistic regression analysis with adjustments for other well-established risk factors revealed that the -607C allele carriers had a significantly increased risk of MI compared with the non-carriers (P<0.05). No relationship between -137G/C polymorphism and MI was found in this study (P=0.133). Compared with the AC haplotype, the CG haplotype was associated with reduced occurrence of MI. CONCLUSIONS: This study shows for the first time that the IL-18 gene promoter -607C/A polymorphism can be considered a genetic risk factor for MI in a Han population of northerb China. CG haplotype is associated with MI occurrence.

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备注/Memo

备注/Memo:
收稿日期：2010-06-18.基金项目：军队“十一五”计划科技攻关课题资助项目(06G021) 通讯作者：韩雅玲，主任医师，主要从事心血管病的基础、临床及介入治疗研究Email：hanyl1976@hotmail.com 作者简介：张效林，主治医师，硕士Email：xiaolindianyu75@sina.com 共同第一作者：裴芳，主治医师，博士Email：cdy060315@163.com
更新日期/Last Update: 2011-03-17