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AT1R基因A1166C的多态性与急性心肌梗死患者冠脉病变程度的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第5期
页码:
613-616,622
栏目:
临床研究
出版日期:
2011-10-25

文章信息/Info

Title:
Association between angiotensin II type 1 receptor gene A1166C polymorphism and extent of coronary stenosis in patients with acute myocardial infarction
作者:
彭建业1; 张 玲1; 尹 凯2; 罗 琼1; 桂庆军2
南华大学：1.附属第二医院心内科，2.诊断学教研室，湖南 衡阳 421001
Author(s):
PENG Jian-ye1;  ZHANG Ling1;  YIN Kai2;  Luo Qiong1;  GUI Qing-jun2
1.Department of Cardiology, Second Affiliated Hospital, 2.Department of Diagnosis, University of South China, Hengyang 421001, Hunan, China
关键词:
血管紧张素Ⅱ1型受体(AT1R); 基因多态性; 急性心肌梗死; 冠脉狭窄
Keywords:
angiotensin II type 1 receptor;  gene polymorphism;  acute myocardial infarction;  extent of coronary stenosis
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的:研究血管紧张素Ⅱ1 型受体(AT1R)基因A1166C的多态性与急性心肌梗死(AMI)患者冠脉病变程度的关系。方法： 采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测105例初发AMI患者的AT1R基因A1166C的多态性。对所有患者进行冠脉造影，根据结果判定冠脉病变的支数(狭窄程度≥50%)和冠脉病变的Gensini积分。结果： AMI患者中，AC+CC基因型携带者冠脉病变的支数和Gensini积分均显著高于AA基因型携带者（P<0.05）。结论： AT1R基因A1166C的多态性与AMI患者冠脉病变程度有关。
Abstract:
AIM:To study the relationship between the angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism and the extent of coronary stenosis in patients with acute myocardial infarction (AMI). METHODS: The A1166C polymorphism of 105 primary AMI patients was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). All patients underwent coronary angiography, and the number of affected coronary vessels (≥50% stenosis) and the coronary Gensini score were determined by the results of coronary angiography. RESULTS: Either the number of affected coronary vessels or the coronary Gensini score in AC+CC genotype carriers was significantly higher than in AA genotype carriers (P<0.05). CONCLUSION: The AT1R gene A1166C polymorphism may be related to the extent of coronary stenosis in AMI patients.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2010-11-23.基金项目：湖南省科技厅科研基金项目资助（2007SK3092） 通讯作者：桂庆军，教授，主要从事冠心病发病机制与防治研究Email:guiqj@yahoo.com.cn 作者简介：彭建业，硕士生Email:pengshengshu@yahoo.cn
更新日期/Last Update: 2011-11-03