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|本期目录/Table of Contents|

β2-微球蛋白与冠心病患者冠脉病变程度的相关性分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第6期
页码:
731-733
栏目:
临床研究
出版日期:
2011-12-25

文章信息/Info

Title:
Correlation between serum β2-microglobulin level and severity of coronary artery disease
作者:
张 斌1; 柴仁杰2; 魏 薇1; 陈小琳1; 李晨曦1; 王 峰1
1.广东省医学科学院、广东省人民医院、广东省心血管病研究所心内科，广东 广州 510080；2.广州医学院第二附属医院心内科，广东 广州 510260
Author(s):
ZHANG Bin1;  CHAI Ren-jie2;  WEI Wei1;  CHEN Xiao-lin1;  LI Chen-xi1;  WANG Feng1
1.Department of Cardiology, General Hospital of Guangdong, Guangzhou 510080, Guangdong, China; 2.Department of Cardiology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China
关键词:
冠状动脉疾病; β2-微球蛋白; SYNTAX积分
Keywords:
coronary artery disease;  β2-microglobulin;  SYNTAX score
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨冠心病患者血清β2-微球蛋白(β2-MG)与冠状动脉粥样硬化病变程度的关系。方法： 选择249例行冠状动脉造影检查的患者,将其分为冠心病组和非冠心病组,用ELISA法检测血清β2-MG水平,依据SYNTAX积分进一步分成亚组,比较各组血清β2-MG水平的差异及与冠状动脉病变程度的相关性。结果： 冠心病组血清β2-MG水平明显高于健康对照组(P<0.01);随着SYTAX积分的升高，冠状动脉病变愈严重,血清β2-MG水平愈高。血清β2-MG水平与冠状动脉狭窄程度呈正相关,相关系数r=0.51(P< 0.01)。结论:冠心病患者血清β2-MG水平与冠状动脉硬化程度呈正相关。
Abstract:
AIM:To investigate the correlation between serum β2-microglobulin (β2-MG) level and coronary stenosis degree in coronary artery disease (CAD). METHODS: A total of 249 patients undergoing selective coronary angiography were enrolled in this study. The patients were classified into the CAD group and the non-CAD group. The immunity transmission turbidity method was applied to measure serum β2-MG concentration. The possible correlation of serum β2-MG level and SYNTAX score were studied by linear correlation. RESULTS: The levels of serum β2-MG in the CAD group were significantly different from those in the control group (P<0.01). Serum β2-MG level increased along with the extents of coronary stenosis and had a positive association with SYNTAX score (r=0.51, P<0.01). CONCLUSION: A positive correlation exists between serum β2-MG level and severity of coronary stenosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2010-11-23.广东省自然科学基金资助（06020821） 通讯作者：张斌，主任医师，主要从事急性冠脉综合症发病机理研究Email:drzhangbin@yahoo.com.cn
更新日期/Last Update: 2011-12-27