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|本期目录/Table of Contents|

糖尿病对应用视网膜血管直径评价冠心病严重程度的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第6期
页码:
794-797
栏目:
临床研究
出版日期:
2011-12-25

文章信息/Info

Title:
Influence of diabetes on severity assessment of coronary atherosclerotic heart disease using diameters of retina vessels
作者:
董 昕1; 2; 兰 琳2; 谢芳元2; 田 刚1
1.西安交通大学医学院第一附属医院心内科，陕西 西安 710061；2.西安市第四医院心内科，陕西 西安 710004
Author(s):
DONG Xin1; 2;  LAN Lin2;  XIE Fang-yuan2;  TIAN Gang1
1.Department of Cardiology, First Affiliated Hospital, Xi’an Jiao Tong University, Xi’an 710061, Shaanxi, China; 2.Department of Cardiology, Fourth Hospital of Xi'an, Xi’an, 710004, Shaanxi, China
关键词:
冠状动脉粥样硬化性心脏病; 糖尿病; 冠状动脉造影; 视网膜
Keywords:
coronary atherosclerotic heart diseases;  diabetes;  coronary arteriography;  retina
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨糖尿病对使用视网膜动脉、视网膜静脉直径评价冠状动脉粥样硬化性心脏病（CHD）患者病变严重程度的影响。方法： 对120例经冠状动脉造影确诊为CHD的患者进行眼底照相，使用Parr-Hubbard公式计算视网膜中央动脉直径等效值（central retinal arteriolar equivalents,CRAE）和视网膜中央静脉直径等效值（central retinal venular equivalents,CRVE），以此分别代表视网膜动脉和视网膜静脉的平均直径。应用Gensini评分标准评价冠状动脉病变程度。通过问卷调查和抽取静脉血获取其他心血管危险因素。研究糖尿病对视网膜血管直径和Gensini评分结果相关性的影响，以及其它心血管危险因素对视网膜血管直径的影响。结果： 糖尿病可使患者的CRVE增加，而对CRAE无影响。糖尿病对Gensini评分与CRAE的相关性具有显著性影响，而不影响Gensini与CRVE的相关性。其他与CRAE有相关性的其他指标有年龄、性别、收缩压、舒张压、平均动脉压、体质量指数、吸烟史、高血压病史和低密度脂蛋白胆固醇、高密度脂蛋白胆固醇。而与CRVE有相关性的有年龄、吸烟史、高血压病史和糖化血红蛋白。结论：视网膜血管直径在一定程度上可反映CHD病变严重程度，但是需考虑到糖尿病及其它心血管危险因素对于评估的影响。
Abstract:
AIM:To investigate the influence of diabetes on the severity assessment of coronary atherosclerotic heart disease (CHD) using diameters of the retina vessels. METHODS: Retina photos were taken in 120 patients who were diagnosed with CHD by coronary arteriography (CAG). Central retinal arteriolar equivalents (CRAE) and central retinal venular equivalents (CRVE) were calculated by Parr-Hubbard formulas, and Gensini scores were obtained. Other cardiovascular risk factors were obtained by questionnaires and venous blood. The influence of diabetes on the relevance between Gensini score and CRAE and CRVE were calculated by covariance analysis, and the influences of other risk factors on the CRAE and CRVE were analyzed by variance and χ2 analysis. RESULTS: Diabetes increased the CRVE in CHD patients but had no obvious effect on CRAE. Diabetes significantly affected the relevance between Gensini score and CRAE, but no such effect was seen between Gensini score and CRVE. Other factors that affected CRAE were age, gender, systolic pressure, diastolic pressure, mean arterial tension, body mass index, current smoking, hypertension, low-density lipoprotein and high-density lipoprotein, whereas the factors that affected CRVE were gender, smoking history, hypertension and HbA1c.CONCLUSION: Diameters of retinal vessels can partly report the severity of CHD, but diabetes and other cardiovascular risk factors should be considered in the severity assessment.

参考文献/References

[1]Wong TY,Cheung N,Islam FMA,et al.Relation of retinopathy to coronary artery calcification:the multi-ethnic study of atherosclerosis[J].Am J Epidemiol,2008,167(1):51-58.

[2]Sun C,Liew G,Wang JJ,et al.Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an asian population:the singapore malay eye study[J].Invest Ophthalmol Vis Sci,2008,49(5):1784-1790.

[3]Hubbard LD,Brothers RJ,King WN,et al.Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities (ARIC) study[J].Ophthalmology,1999,106(12):2269-2280.

[4]Sabanayagam C,Tai ES,Lee J,et al. Retinal vessel caliber and peripheral neuropathy in diabetic articipants[J].Microcirculation,2010,17(4):297-302.

[5]Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606-607.

[6]Cheung N,Rogers S,Mosley TH,et al.Vital exhaustion and retinal microvascular changes in cardiovascular disease:atherosclerosis risk in communities study[J].Psychosom Med,2009,71(3):308-312.

[7]Preiss D,Sattar N,McMurray JJ.A systematic review of event rates in clinical trials in diabetes mellitus: The importance of quantifying baseline cardiovascular disease history and proteinuria and implications for clinical trial design[J].Am Heart J,2011,161(1):210-219.

[8]Su G,Mi S,Tao H,et al.Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes[J].Cardiovasc Diabetol,2011,10:19.

[9]Sun C,Wang JJ,Mackey DA,et al.Retinal Vascular Caliber: Systemic, Environmental,and Genetic Associations[J].Surv Ophthalmol,2009,54(1):74-95.

[10]张红丽,胡晓芸,许建英,等.烟雾暴露时间及吸入量对大鼠肺血管形态的影响[J].国际呼吸杂志,2009,29(9):538-541.

[11]Popescu RM,Cotutiu C,Graur M,et al.Vascular and nerve lesions of the diabetic foot- a orphological study[J].Rom J Morphol Embryol,2010,51(3):483-488.

[12]王 晖，杨志健,马根山,等.血管紧张素Ⅱ-1型受体基因多态性与冠状动脉血管病变及支架内再狭窄的关系[J].心脏杂志,2003,15(4):303-305.

备注/Memo

备注/Memo:
收稿日期：2011-01-02.通讯作者：田刚，主任医师，主要从事高血压的研究Email：tiangang36@yahoo.com.cn 作者简介：董昕，主治医师，硕士生Email：longtan1@sina.com
更新日期/Last Update: 2011-12-27