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Title:: Effects of intravenous recombinant human brain natriuretic peptide on patients after transcatheter closure of atrial septal defect

作者:: 姚玮¹; 高印生¹; 王晓璞²; 王旭初¹; 巩祥胜¹; 祁国奇²; 赵建峰¹; (1.沧州中西医结合医院介入治疗科，河北沧州 061000；2.河北医科大学第二医院心脏外科，河北石家庄 050000)

Author(s):: YAO Wei¹; GAO Yin-sheng¹; WANG Xiao-pu²; WANG Xun-chu¹; GONG Xiang-sheng¹; QI Guo-qi²; ZHAO Jian-feng¹; (1.Department of Interventional Treatment, Cangzhou Integrated Traditional and Western Medical Hospital, Cangzhou 061001, Hebei, China; 2.Department of Cardiovascular Surgery, Second Hospital, Hebei Medical University, Shijiazhuang, 050000, Hebei, China)

关键词:: 重组人脑钠尿肽; 房间隔缺损; 肺动脉高压; 6分钟步行试验距离

Keywords:: recombinant human brain natriuretic peptide; atrial septal defect; pulmonary hypertension; 6-minute walking distance

分类号:: R541.1

DOI:: -

文献标识码:: A

摘要:: 目的:探讨重组人脑钠尿肽（recombinant human brain natriuretic peptide,rhBNP）对房间隔缺损(ASD)并发肺动脉高压封堵术后的肺动脉高压的影响。方法：选择56例房间隔缺损并发中重度肺动脉高压患者封堵成功患者,将其随机分为术后静脉点滴rhBNP患者为处理组（30例），未应用的为对照组（26例），比较两组术前、术后48 h及术后6个月肺动脉压、6分钟步行试验距离（six minute walking distance，6MWD）、血浆内皮素(endothelin,ET)水平的变化。结果：在术后48 h和术后6个月，两组患者肺动脉压及ET水平术后明显降低（P<0.05）；两组患者6MWD较术前显著增加(P<0.05)；术后48 h和术后6个月处理组较对照组显著降低肺动脉压及ET水平（P<0.01），显著增加6MWD(P<0.01)。结论：封堵术后静脉点滴rhBNP可进一步降低肺动脉压及ET水平，增加6MWD。

Abstract:: AIM:To investigate the effectiveness of intravenous recombinant human brain natriuretic peptide (rhBNP) on pulmonary hypertension (PH) in patients undergoing transcatheter closure of atrial septal defect (ASD). METHODS: Fifty-six cases of ASD with PH were treated with transcatheter closure and patients were randomly divided into treatment group (30 patients) and control group (26 patients). Patients in the treatment group were given rhBNP i.v. after closure of patent ductus arteriosus, and changes of pulmonary artery pressure, endothelin (ET) and 6-min walking distance (6MWD) were tested and compared between groups 48 h and 6 months after treatment. RESULTS: Results were similar in the two groups 48 h and 6 months after treatment. Postoperative levels of pulmonary artery pressure and postoperative ET were significantly lower than preoperative levels (P<0.05) and 6MWD increased significantly (P<0.05). However, levels of pulmonary artery pressure and ET of the treatment group were significantly lower than those of the control groups after i.v. administration of recombinant brain natriuretic peptide (P<0.01). 6MWD significantly increased compared with that of the control group (P<0.01). CONCLUSION: rhBNP further reduces pulmonary artery pressure and improves cardiac function in patients with PH after transcatheter closure of ASD.

参考文献/References

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房间隔缺损封堵术后应用重组人脑钠尿肽的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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