我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血压正常高值者血压晨峰与冷加压试验的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第2期
页码:
193-196
栏目:
临床研究
出版日期:
2012-04-25

文章信息/Info

Title:
Association between morning blood pressure surge and cold pressure test in prehypertensive patients
作者:
刘振东1; 2; 董元丽3; 路方红2; 赵颖馨2; 孙尚文2; 王舒健2; 王 琳1
(1.华中科技大学同济医学院附属同济医院心内科，湖北 武汉430030；2.山东省医学科学院基础医学研究所心脑血管病防治研究中心，山东 济南 250062；3.山东省临沂市兰山区第一人民医院内科，山东 临沂 256002)
Author(s):
LIU Zhen-dong1; 2;  DONG Yuan-li3;  LU Fang-hong2;  ZHAO Ying-xin2;  SUN Shang-wen2;  WANG Shu-jian2;  WANG Lin1
(1.Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; 2.Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China; 3.Department of Internal Medicine, First People’s Hospital of Lanshan, Linyi 256002, Shandong, China)
关键词:
血压正常高值; 交感神经活性; 血压晨峰; 冷加压试验
Keywords:
prehypertension;  sympathetic nervous activity;  morning blood pressure surge;  cold pressure test
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的:探讨血压正常高值者血压晨峰现象与冷加压试验后血压变化的相关性。方法：将258例受试者按血压水平分为理想血压组、血压正常高值组和高血压病组。所有受试者均进行24小时动态血压监测及冷加压试验。结果：血压正常高值者清晨血压上长幅度为（27±9）mmHg，冷加压后0 s及60 s SBP增加幅度分别为(14±6)mmHg及(9±5)mmHg，晨峰及冷加压试验阳性发生率分别为45%及26%，低于高血压病组，但明显高于理想血压组（P<0.05）。血压晨峰、吸烟史、年龄及高密度脂蛋白胆固醇是影响0 s SBP增加幅度的主要因素；血压晨峰、年龄及空腹血糖是影响60 s SBP增加幅度的主要因素。结论：血压正常高值者清晨血压上升明显，冷加压后血压显著上升，冷加压后血压增幅与血压晨峰相关。
Abstract:
AIM:To explore the association between morning blood pressure surge and changes of blood pressure after cold pressure test in prehypertensive patients. METHODS: According to blood pressure levels, 258 subjects were divided into three groups, namely, normotensive group, prehypertensive group and hypertensive group. Twenty-four hour ambulatory blood pressure monitoring and cold pressure test were conducted in all subjects. RESULTS: Morning blood pressure surge was (27±9) mmHg and the increased amplitude of systolic blood pressure at 0 and 60 sec after cold pressure test was (14±6) mmHg and (9±5) mmHg, respectively. The rate of positive morning blood pressure surge and cold pressure test was 45% and 26% in prehypertensive group, lower than that in the hypertensive group but significantly higher than that in the normotensive group (P<0.05). Morning blood pressure surge, smoking history, age and high-density lipoprotein were important factors for the increased amplitude of systolic blood pressure at 0 sec after cold pressure test. Morning blood pressure surge, age and fasting plasma glucose were important factors for the increased amplitude of systolic blood pressure at 60 sec after cold pressure test. CONCLUSION: Sympathetic nervous system activity was enhanced in prehypertensive patients. Blood pressure was significantly elevated in the morning and after cold pressure test in prehypertensive patients. Increased amplitude of blood pressure after cold pressure test is associated with morning blood pressure surge in prehypertensive patients.

参考文献/References

[1]赵 冬，李翠芬,王 薇,等.正常高值血压人群10年心血管病发病危险的分析[J].中华老年心脑血管病杂志,2006, 8(11):730-733.

[2]Guzik P,Wykretowicz A,Krauze T,et al.Add-on therapy with a night-time dose of doxazosin in patients with uncontrolled hypertension: effects on atutonomic modulation of the cardiovascular system[J].Hypertens Res,2008,31(3):433-453.

[3]马丽娜,冯 明,马 佳.老年原发性高血压患者晨峰现象与左心室肥厚[J].心脏杂志,2010,22(2):225-227.

[4]康玉华,王瑞英,冯 品,等. 高血压患者血压晨峰与早期肾功能损害的相关性[J].中华高血压杂志,2011,19(2):182-185.

[5]Flaa A,Eide IK,Kiekdsen SE,et al.Sympathoadrenal stress reactivity is a predictor of future blood pressure:an 18-year follow-up study[J].Hypertension,2008,52(2):336-341.

[6]Lee DH,Ihm SH, Youn HJ, et al. Age is an independent risk factor for the early morning blood pressure surge in patients never treated for hypertension[J].Korean Circ J,2009,39(8):322-327.

[7]Wood DL, Sheps SG,Elveback LR,et al.The cold pressure test as a predictor of hypegension[J].Hypertension,1984, 6(3):301-306.

[8]Yang J,Lu F,Zhang C,et al.Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007[J]. Hypertens Res,2010,33(4):331-337.

[9]De Marco M,de Simone G,Roman MJ,et al.Cardiovascular and metabolic predictors of progression of prehypertension into hypertension:the Strong Heart Study[J].Hypertension,2009,54(4):974-980.

[10]姚光涛,路方红,刘振东,等.血压正常高值者24小时动态血压分析[J].心脏杂志,2010，22(6):864-867.

[11]Giles TD.Circadian rhythm of blood pressure and the relation to cardiovascular events[J].J Hypertesn Suppl,2006,24(2):S11-S16.

[12]潘 慧,路方红,赵颖馨,等.老年血压正常高值者中心动脉压与颈动脉内膜中层厚度的相关研究[J].中华老年心脑血管病杂志,2011,13(3):235-237.

[13]Manios E,Tsivgoulis G,Koroboki E,et al.Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass[J].Stroke,2009,40(4):1515-1518.

[14]Pimenta E,Gaddam KK,Pratt-Ubunama MN,et al.Aldosterone excess and resistance to 24-h blood pressure control[J].J Hypertens,2007,25(10):2131-2137.

[15]Eguchi K,Tomizawa H,Ishikawa J, et al.Factors associated with baroreflex sensitivity:association with morning blood pressure[J]. Hypertens Res,2007,30(8):723-728.

[16]刘 杰,曹铁生,段云友,等.冷加压试验研究血压及血管反应性对动脉弹性参数的影响[J].中华超声影像学杂志,2009,18(7):575-577.

备注/Memo

备注/Memo:
收稿日期：2011-07-29.基金项目：山东省自然科学基金项目资助（ZR2009CL029）；山东省医药卫生计划项目资助（2009HW080）；山东省医学科学院项目资助（2009-16、2009-17）通讯作者：王琳，主任医师，主要从事心律失常的诊治研究 Email:wangling@tjh.tjmu.edu.cn 作者简介：刘振东，副主任医师，博士生 Email:zhendongliu876@126.com
更新日期/Last Update: 2012-04-01