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|本期目录/Table of Contents|

不同性别冠心病危险因素与冠脉病变程度的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第2期
页码:
205-208,218
栏目:
临床研究
出版日期:
2012-04-25

文章信息/Info

Title:
Relationship between cardiovascular risk factors and severity of coronary artery disease in patients of both genders
作者:
俞阅彦; 江时森; 宋宏宾; 刘念念
(南京军区南京总医院心脏内科，江苏 南京 210002)
Author(s):
YU Yue-yan;  JIANG Shi-sen;  SONG Hong-bin;  LIU Nian-nian
(General Hospital, Nanjing Military Area Command, Nanjing 210002, Jiangsu, China)
关键词:
冠状动脉疾病; 危险因素; 性别; 冠脉病变程度
Keywords:
coronary disease;  risk factors;  gender;  severity;  coronary artery disease
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:分析冠心病危险因素与冠状动脉病变程度的相关性及其性别差异。方法：入选2005年～2009年入院行冠状动脉造影术的患者1 786（男1 214，女572）例，记录性别、年龄、血压、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、血糖、吸烟等指标，并计算Gensini积分。首先，根据Gensini积分将所有患者分成4个组，对各个组之间的各项危险因素分别进行比较分析。然后用Logistic回归分析法比较冠心病与各项危险因素之间的相关程度，最后通过性别分组再次行Logistic回归比较不同性别冠心病与各项危险因素之间的相关程度。结果：单因素分析发现随着Gensini积分的增高年龄、TC、LDL-C也增加，而HDL-C下降，但TG、UA在各组中无统计学差异，且各个小组中随着男性、吸烟者、高血压病、糖尿病比例的增加冠脉病变积分增高；多危险因素与冠状动脉造影诊断冠心病Logistic分析：糖尿病为冠心病最显著的独立危险因素，其他依次为吸烟、低HDL-C、高LDL-C、增龄、性别，而高血压病与高TC均无统计学意义。性别分组后，男性患者中吸烟为冠心病最显著的独立危险因素，其他依次为低HDL-C、高LDL-C、糖尿病、增龄；女性患者中糖尿病为最显著的独立危险因素，其次是低HDL-C、增龄，吸烟对女性冠心病的发生无显著性差异。结论：年龄的增加、TC的增加、LDL-C的增加、HDL-C的降低、高血压、糖尿病、吸烟等危险因素都会加重冠脉病变程度，其中糖尿病是冠心病最显著的危险因素,尤其在女性更为明显。
Abstract:
AIM:To analyze the relationship between cardiovascular risk factors and the severity of coronary artery disease (CHD) and to evaluate the relevance of risk factors and CHD and gender differences. METHODS: A total of 1 786 patients (1 214 males and 572 females) who underwent coronary angiography were selected, and their gender, ages, blood pressure, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), uric acid (UA), blood sugar and smoking history were recorded and calculated by the Gensini score. All cases were divided into four groups according to Gensini score. Risk factors were compared among the various groups, and the relationship of CHD and risk factors was first analyzed generally and then analyzed by gender with logistic regression. RESULTS: Univariate analysis of CHD risk factors and relevance of coronary lesions showed that Gensini score increased with the increase of age, TC and LDL, whereas HDL decreased. No significance difference was found in TC and UA between groups. Gensini score also increased in males, smokers, and patients with hypertension and diabetes. Logistic regression analysis showed that the most significant risk factors for CHD were diabetes followed by smoking, low HDL, high LDL, aging and gender, but no significant difference was found in hypertension (P=0.10) and high TG (P=0.29). Analysis by gender showed that smoking was the most significant risk factors for males followed by low HDL, high LDL, diabetes and aging. Diabetes was the most significant risk factor for females followed by low HDL. Aging and smoking were not significant factors for females. CONCLUSION: Increasing age, TC, LDL, HDL, hypertension, diabetes and smoking are risk factors shown to increase the severity of CHD, among which diabetes is one of the most significant CHD risk factors, particularly for females.

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备注/Memo

备注/Memo:
收稿日期：2011-09-15.通讯作者：江时森，主任医师，主要从事心内科基础和临床研究 Email：wwwjiangshisen@sina.com 作者简介：俞阅彦，硕士生 Email: yuyueyan0919@163.com
更新日期/Last Update: 2012-04-01