我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

睾酮对钙离子通道和心脏功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第2期
页码:
275-278,280
栏目:
综述
出版日期:
2012-04-25

文章信息/Info

Title:
Effect of testosterone on calcium channels and cardiac function
作者:
周玉文1; 2; 曹雪滨2; 徐 鹏2; 张 燕3; 江明宏2
(1.河北大学中医学院，河北 保定 071000；2.解放军第252医院心内科，河北 保定 071000；3.保定市第一医院心内科，河北 保定 071000)
Author(s):
ZHOU Yu-wen1; 2;  CAO Xue-bin2;  XU Peng2;  ZHANG Yan3;  JIANG Ming-hong2
(1.College of Traditional Chinese Medicine, Hebei University, Baoding 071000, Hebei, China; 2.Department of Cardiology, PLA 252 Hospital, Baoding 071000, Hebei, China; 3.Department of Cardiology, First Hospital of Baoding, Baoding 071000, Hebei, China)
关键词:
睾酮; 钙离子通道; 心脏功能
Keywords:
testosterone;  calcium channels;  cardiac function
分类号:
Q579.11
DOI:
-
文献标识码:
A
摘要:
睾酮对人体的全身代谢、心脏的生理和病理均有着重要的影响。较高浓度的睾酮或其慢性作用可以提高T型、L型钙离子通道的密度，较低浓度或急性作用可以阻滞T型、L型钙离子通道，缩短男性Q-Tc 间期，提高对胰岛素的敏感性及改善血脂代谢。睾酮可上调钙调节蛋白、β2受体的表达，在提高细胞内钙离子浓度的情况下，可增加钙瞬变的幅度，减少钙超载。一定浓度的睾酮可以维持血管的一定张力，改善心脏传导或扩张冠脉；减少胰岛素抵抗、代谢综合征的发生，改善心肌缺血、减少心肌细胞凋亡及纤维化，保护心脏，改善心脏收缩舒张效率。
Abstract:
Testosterone has important effects on human body metabolism, physiology and cardiac pathology. Higher concentrations of testosterone or its chronic effects can increase T- and L-type calcium channel density and lower concentrations or acute effects can block T- and L-type calcium channels, reduce male Q-Tc period and improve sensitivity to insulin and lipid metabolism. Testosterone can increase calcium regulatory proteins and expression of beta-2 receptor, enhance calcium transit rate and reduce calcium overload in case of increase of intracellular calcium concentration. Appropriate concentration of testosterone can sustain a certain vascular tension, improve cardiac conduction or dilate coronary arteries, reduce insulin resistance and incidence of metabolic syndrome, improve myocardial ischemia, reduce apoptosis and myocardial cell fibrosis, protect the heart and enhance cardiac diastolic efficiency.

参考文献/References

[1]Michels G,Er F,Eicks M,et al.Long-term and immediate effect of testosterone on single T-type calcium channel in neonatal rat cardiomyocytes[J].Endocrinology,2006,147(11):5160-5169.

[2]王蓓蕾,肖 良,张黎明.心肌细胞中线粒体的Ca2+信号转导[J].心脏杂志,2011,23(5):670-672,678.

[3]Monta o LM,Calixto E,Figueroa A,et al.Relaxation of androgens on rat thoracic aorta:testosterone concentration dependent agonist/antagonist L-type Ca2+channel activity, and 5beta-dihydrotestosterone restricted to L-type Ca2+ channel blockade[J].Endocrinology,2008,149(5):2517-2526.

[4]Scragg JL,Jones RD,Channer KS,et al.Testosterone is a potent inhibitor of L-type Ca2+ channels[J].Biochem Biophys Res Commun,2004,318(2):503-506.

[5]Schwartz JB,Volterrani M,Caminiti G,et al.Effects of testosterone on the Q-T Interval in older men and older women with chronic heart failure[J].Int J Androl,2011,34(5 Pt 2):e415- e421.

[6]Yialamas MA,Dwyer AA,Hanley E,et al.Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism[J].J Clin Endocrinol Metab,2007,92(11):4254-4259.

[7]Agirbasli M,Agaoglu NB,Orak N,et al.Sex hormones,insulin resistance and high-density lipoprotein cholesterol levels in children[J].Horm Res Paediatr,2010,73(3):166-174.

[8]Wehr E,Pilz S,Boehm BO,et al.Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women[J].Diabetes Care,2011,34(8):1771-1777.

[9]Allan CA,McLachlan RI.Androgens and obesity[J].Curr Opin Endocrinol Diabetes Obes,2010,17(3):224-232.

[10]Corona G,Rastrelli G,Monami M,et al.Hypogonadism as a risk factor for cardiovascular mortality in men:a meta-analytic study[J].Eur J Endocrinol,2011,165(5):687-701.

[11]Liu AY,Gao LP,Kang SL,et al.Testosterone enhances estradiol’s cardioprotection in ovariectomized rats[J].J Endocrinol,2011,212(1):61-69.

[12]Carson Iii CC,Rosano G.Exogenous testosterone, cardiovascular events, and cardiovascular risk factors in elderly men: a review of trial data[J].J Sex Med,2012,9(1):54-67.

[13]Sun J,Fu L,Tang X,et al.Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure[J].Gen Comp Endocrinol,2011,172(3):518-525.

[14]Tsang S,Liu J,Wong TM.Testosterone and cardioprotection against myocardial ischemia[J]. Cardiovasc Hematol Disord Drug Targets,2007,7(2):119-125.

[15]Chahla EJ,Hayek ME, Morley JE.Testosterone replacement therapy and cardiovascular risk factors modification[J]Aging Male,2011,14(2):83-90.

[16]Lee HC.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling[J].Sci China Life Sci,2011,54(8):699-711.

[17]Gan L,Jiang W,Xiao YF,et al.Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice[J]Life Sci,2011,89(13-14):491-499.

备注/Memo

备注/Memo:
收稿日期：2011-10-23.基金项目：军队中医药科研专项课题项目资助（10zyz106） 通讯作者：曹雪滨，教授，主要从事心力衰竭的研究 Email：cxb@yahoo.com.cn 作者简介：周玉文，硕士生 Email：438710374@qq.com
更新日期/Last Update: 2012-04-01