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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2012年第3期

页码:

347-349,357

栏目:

临床研究

出版日期:

2012-06-25

文章信息/Info

Title:

Structural remodeling-related factors can predict structural remodeling of left atrium in patients with atrial fibrillation without structural heart disease

作者:

李茜楠¹; 曹 威²; 崔金金¹; 李述峰²; 田 振³; 田 野¹

(哈尔滨医科大学：1.附属第一医院心内科，2.附属第二医院心内科，3.病理生理学教研室，黑龙江 哈尔滨 150086)

Author(s):

LI Qian-nan¹;  CAO Wei²;  CUI Jin-jin¹;  LI Shu-feng²;  TIAN Zhen³;  TIAN Ye¹

(1.Department of Cardiology, First Affiliated Hospital, 2.Department of Cardiology, Second Affiliated Hospital, 3.Department of Pathophysiology, Harbin Medical University, Harbin 150086, Heilongjiang, China)

关键词:

心房颤动; 基质金属蛋白酶-9; 金属蛋白酶组织抑制因子-1; 转化生长因子-β1; 结构重构

Keywords:

atrial fibrillation;  matrix metalloproteinases-9;  metalloproteinase-1;  transforming growth factor-beta 1;  structural remodeling

分类号:

R541.61

DOI:

-

文献标识码:

A

摘要:

目的:探讨无结构性心脏病房颤患者的左房或右房基质金属蛋白酶-9（MMP-9）、金属蛋白酶组织抑制因子-1（TIMP-1）、转化生长因子-β1（TGF-β1）和碱性成纤维细胞生长因子（bFGF）血清水平与心房结构重构的关系。方法： 通过ELISA方法检测42例无结构性心脏病房颤患者及17例阵发性室上速或预激综合征患者左房和右房中血清的MMP-9、TIMP-1、TGF-β1和bFGF水平，并使用超声心动图测量左心房长径。分析血清中上述细胞因子的水平与房颤左房结构重构程度的关系。结果： 房颤组左房内径(36±7) mm显著高于对照组(31±4) mm（P<0.01）；房颤组左房血清MMP-9为(3037±804) ng/L，明显高于对照组(2439±663) ng/L（P<0.01）和右房(2635±9308) ng/L（P<0.05），但右房血清MMP-9与对照组相比未见显著性差异；与对照组相比，房颤组TIMP-1明显降低（P<0.05），TGF-β1明显升高（P<0.01），bFGF无显著性差异；MMP-9/TIMP-1与左房内径呈正相关。结论： MMP-9、TIMP-1和TGF-β1与房颤相关，并可提示房颤的结构重构程度。

Abstract:

AIM:To investigate the significance of matrix metalloproteinases-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), transforming growth factor-beta 1 (TGF-β1) and basic fibroblast growth factor (bFGF) serum level related to atrial structural remodeling in atrial fibrillation (AF) patients without structural heart disease. METHODS: Serum samples were taken from, respectively, left atrium and right atrium of 42 AF patients without structural heart disease and 17 paroxysmal supraventricular tachycardia or patients with Wolff-Parkinson-White (WPW) syndrome who underwent catheter ablation. Pre-ablation plasma concentrations of MMP-9, TIMP-1, TGF-β1 and bFGF were evaluated by ELISA. Left atrial diameter (LAD) was detected by echocardiography. RESULTS: LAD in AF group (36±7) mm was statistically higher than in control group (31±4) mm. MMP-9 serum level of the left atrium in the AF group (3037±804) pg/ml was statistically higher than in the control group (2439±663) pg/ml (P<0.01) and the level in the right atrium (2635±930.38) pg/ml (P<0.05). Right atrium MMP-9 levels in the AF group (2635.35±930.38) pg/ml were similar to the control group (2762.34±802.53) pg/ml (P>0.05). TIMP-1 level in AF group was statistically lower than in control group (P<0.05) and TGF-β1 level in the AF group was statistically higher than control group (P<0.05). No significant difference in bFGF level was found between AF and control groups. MMP9 serum level and LAD in AF group was linearly correlated (0.447, P<0.01). CONCLUSIONS: MMP-9, TIMP-1 and TGF-β1 are closely related to the occurrence of AF and can be used to predict the structural remodeling of left atrium in patients with AF.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2012-01-13.基金项目：国家自然科学基金资助（81171483），黑龙江省卫生厅课题资助（2011-102），中国博士后基金资助（2011M501060） 通讯作者：田野，教授，主要从事声动力对动脉粥样硬化斑块影响的研究 Email:tianeast@hotmail.com 作者简介：李茜楠，硕士生 Email:liqiannanbs@163.com

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更新日期/Last Update: 2012-05-02