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|本期目录/Table of Contents|

茶多酚与心血管疾病的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第3期
页码:
398-401
栏目:
综述
出版日期:
2012-06-25

文章信息/Info

Title:
Tea polyphenols and cardiovascular diseases: research progress
作者:
杨 剑1; 2综述; 曾春雨2审校
(第三军医大学大坪医院 野战外科研究所：1.营养科，2.心血管病专科医院心内科、重庆心血管病研究所,重庆 400042)
Author(s):
YANG Jian1; 2;  ZENG Chun-yu2
(1.Department of Nutrition, 2.Department of Cardiology, Hospital of Cardiology, Chongqing Institute of Cardiology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China)
关键词:
茶多酚; 心血管疾病; 动脉粥样硬化; 高血压
Keywords:
tea polyphenols;  cardiovascular disease;  atherosclerosis;  hypertension
分类号:
R282.71；R54
DOI:
-
文献标识码:
A
摘要:
茶多酚(tea polyphenols，TPP)及其主要生物活性成分在防治心血管疾病中的作用广泛，具有明确的抗氧化、抗动脉粥样硬化、降血压、降血脂、保护心脏等多种药理作用。而且，TPP对心血管系统的保护作用在多个临床研究中已得到证实。同时，TPP还具有安全性较高、毒副作用较小等优点，这些均使其在临床与生活中具有广泛的应用空间，并为心血管疾病的防治提供了新的思路。
Abstract:
Tea polyphenols and their main biologically active components have many beneficial effects on cardiovascular disease such as anti-oxidation, anti-atherosclerosis, decreased blood pressure, lowered blood lipids and cardioprotection. The beneficial effects of tea polyphenols in cardiovascular diseases have been confirmed in many clinical studies. For reasons of increased safety and decreasing side effects, tea polyphenols have wider application in both clinical treatment and daily life. Tea polyphenols have provided a new approach for the prevention and treatment of cardiovascular diseases.

参考文献/References

[1]Mulvihill EE,Huff MW.Antiatherogenic properties of flavonoids: implications for cardiovascular health[J].Can J Cardiol,2010,26(Suppl A):17A-21A.

[2]Yang H,Landis-Piwowar K,H Chan T,et al.Green tea polyphenols as proteasome inhibitors: implication in chemoprevention[J].Curr Cancer Drug Targets,2011,11(3):296-306.

[3]Han DW,Lee MH,Kwon BJ,et al.Selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cells[J].Molecules,2010,15(11):8488-8500.

[4]Lo HM,Hung CF,Huang YY,et al.Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction[J].J Biomed Sci,2007,14(5):637-645.

[5]Chae YJ,Kim CH,Ha TS,et al.Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways[J].Cell Physiol Biochem,2007,20(6):859-866.

[6]Wang CJ,Liu JT,Guo F.(-)-epigallocatechin gallate inhibits endothelin-1-induced C-reactive protein production in vascular smooth muscle cells[J].Basic Clin Pharmacol Toxicol,2010,107(2):669-675.

[7]Potenza MA,Marasciulo FL,Tarquinio M,et al.EGCG,a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR[J].Am J Physiol Endocrinol Metab,2007, 292(5):E1378-E1387.

[8]Ikeda M,Suzuki C,Umegaki K,et al.Preventive effects of green tea catechins on spontaneous stroke in rats[J].Med Sci Monit,2007,13(2):BR40-BR45.

[9]Antonello M,Montemurro D,Bolognesi M,et al.Prevention of hypertension,cardiovascular damage and endothelial dysfunction with green tea extracts[J].Am J Hypertens,2007,20(12):1321-1318.

[10]Dong J,Xu X,Liang Y,et al.Inhibition of angiotensin converting enzyme (ACE) activity by polyphenols from tea (Camellia sinensis) and links to processing method[J].Food Funct,2011,2(6):310-319.

[11]Yanagi S,Matsumura K,Marui A,et al.Oral pretreatment with a green tea polyphenol for cardioprotection against ischemia-reperfusion injury in an isolated rat heart model[J].J Thorac Cardiovasc Surg,2011,141(2):511-517.

[12]Song DK,Jang Y,Kim JH,et al.Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts[J].J Korean Med Sci,2010,25(3):380-386.

[13]Sheng R,Gu ZL,Xie ML,et al.EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy[J].Planta Med,2009,75(2):113-120.

[14]Sheng R,Gu ZL,Xie ML,et al.EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats[J].Acta Pharmacol Sin,2007,28(2):191-201.

[15]Devika PT, Mainzen Prince PS.(-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases[J].J Pharm Pharmacol,2008,60(1):125-133.

[16]de Koning Gans JM,Uiterwaal CS,van der Schouw YT,et al.Tea and coffee consumption and cardiovascular morbidity and mortality[J].Arterioscler Thromb Vasc Biol,2010,30(8):1665-1671.

[17]Mineharu Y,Koizumi A,Wada Y,et al.Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women[J].J Epidemiol Community Health,2011,65(3):230-240.

[18]Inami S,Takano M,Yamamoto M,et al.Tea catechin consumption reduces circulating oxidized low-density lipoprotein[J].Int Heart J,2007,48(6):725-732.

[19]Tinahones FJ,Rubio MA,Garrido-Sánchez L,et al.Green tea reduces LDL oxidability and improves vascular function[J].J Am Coll Nutr,2008,27(2):209-213.

备注/Memo

备注/Memo:
收稿日期：2011-10-07.基金项目：国家杰出青年科学基金项目资助(30925018)；重庆 市杰出青年科学基金项目资助(CSTC 2009BA5044)；国家自然科学基金项目资助(81100500) 通讯作者：曾春雨，教授，主要从事高血压及相关疾病研究 Email:chunyuzeng01@163.com 作者介绍：杨剑，主治医师，博士 Email:yangjianac@163.com
更新日期/Last Update: 2012-05-02