我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

混合高脂饲料喂养新西兰白兔建立DHF模型的实验

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
435-437
栏目:
基础研究
出版日期:
2012-08-25

文章信息/Info

Title:
Establishment of diastolic heart failure model in New Zealand white rabbits by mixed high-fat diet
作者:
薛礼美1; 唐蜀华2; 鞠晓云3
(1.苏州市中医医院内科，江苏 苏州 215000；2.江苏省中医院心内科，江苏 南京 210029；3.南京中医药大学动物实验室，江苏 南京 210029)
Author(s):
XUE Li-mei1;  TANG Shu-hua2;  JU Xiao-yun3
(1.Department of Cardiology, Su Zhou Hospital of Traditional Chinese Medicine, Suzhou 215000, Jiangsu, China; 2.Department of Cardiology, Jiang Su Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu, China; 3.Department of Animal Laboratory, Nan Jing University of Traditional Chinese Medicine, Nan Jing 210029, Jiang Su, China)
关键词:
舒张性心力衰竭; 动物模型; 新西兰白兔
Keywords:
New Zealand white rabbit;  diastolic heart failure;  animal model
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:建立兔舒张性心力衰竭(DHF)模型。方法： 采用混合高脂饲料喂养新西兰白兔12周，并设正常饲料组进行对照观察。结果： 高脂组与空白对照组比较，高脂组有心力衰竭的症状、体征，在心率、左心室收缩期最大压力上升速率(LV+dp/dtmax)、左室收缩指数（S-1）没有差异，在左室收缩压（LVSP）、左心室舒张末压(LVEDP)、左室压力最大下降速率(LV-dp/dtmax)有显著差异（P<0.05），符合DHF动物模型。结论： 采用混合高脂饲料喂养新西兰白兔可建立DHF模型。
Abstract:
AIM:To establish the diastolic heart failure model in New Zealand white rabbits using a noninvasive method. METHODS: The model group established by New Zealand white rabbits fed a mixed high-fat diet for 12 weeks compared with the normal group established by New Zealand white rabbits fed a normal diet for the same time. RESULTS: Model group showed signs and symptoms of heart failure. In the model group compared with control group, no differences were shown in heart rate, left ventricular systolic maximum rate of pressure increase (LV+dp/dtmax), left ventricular systolic index (S-1) but in LVSP, contraction index, left ventricular systolic pressure rise rate, left ventricular end diastolic pressure, decreased maximum rate of left ventricular pressure (LV-dp/dtmax) were significantly different (P<0.05), in accordance with diastolic heart failure animal model. CONCLUSION: New Zealand white rabbits fed a mixed high-fat diet can create an animal model of diastolic heart failure.

参考文献/References

[1]张 运.舒张性心力衰竭的研究进展[J].心肺血管病杂志,2004,23(1):51-55.

[2]Carroll JF,Summers RL,Dzielak DJ,et al.Diastolic compliance is reduced in obese rabbits[J].Hypertension,1999,33(3):811-815.

[3]Dougherty AH,Naccarelli GV,Gray EL,et al.Congestive heart failure with normal systolic function[J].Am J Cardiol,1984,54(7):778-782.

[4]How to diagnose diastolic heart failure.European Study Group on Diastolic Heart Failure[J].Eur Heart J,1998,19(7):990-1003.

[5]Owan TE,Hodge DO,Herges RM,et al.Trends in prevalance and outcome of heart failure with preserved ejection fraction[J].N End J Med,2006,355(3):251-259.

[6]Abhayaratna WP,Marwick TH,Smith WT,et al.Characteristics of left ventricular diastolic dysfunction in the community:an echocardiographic survey[J].Heart,2006,92(9):1259-1264.

[7]袁 洪.高血压病的个体化治疗[M].北京:人民卫生出版社,2009:155.

[8]邹亚群,刘学宁.粟米油对心脑血管疾病治疗保健作用的探讨[J].中国公共卫生管理,2002,18(1):71-73.

[9]Chatterjee K,Massie B.Systolic and diastolic heart failure:differences and similarities[J].J Card Fail,2007,13(7):569-576.

[10]蔡 毅,何昆仑,闫丽辉,等.新西兰兔腹主动脉缩窄术(肾动脉上)后心肌收缩和舒张功能的变化[J].中国康复理论与实践2007,13(3):245-247.

[11]王 蕾,王海鹏.兔舒张性心衰和收缩性心衰模型建立及间质重构的比较[J]. 基础医学与临床,2009,29(12):1244-1249.

[12]王 亮,朱 兵,何昆仑.慢性缺血性舒张心力衰竭动物模型的建立[J].中华保健医学杂志,2010,12(1):19-20.

备注/Memo

备注/Memo:
收稿日期：2011-08-12.通讯作者：唐蜀华，主任医师，主要从事心力衰竭的研究Email：tangshuhua7878@163.com 作者简介：薛礼美，副主任医师，硕士Email：xuelimei-800320@163.com
更新日期/Last Update: 2012-07-20