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|本期目录/Table of Contents|

中国北方汉族人群IL-8基因+394 T/G多态性与急性冠脉综合征的关联性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
442-445
栏目:
临床研究
出版日期:
2012-08-25

文章信息/Info

Title:
Association of interleukin-8 +394 T/G with acute coronary syndrome in a Han population in Northern China
作者:
张效林; 张保海; 梁振洋; 孙 莹; 冯雪瑶; 韩雅玲
(沈阳军区总医院心内科，辽宁 沈阳 110084)
Author(s):
ZHANG Xiao-lin;  ZHANG Bao-hai;  LIANG Zhen-yang;  SUN Ying;  FENG Xue-Yao;  HAN Ya-ling
(Department of Cardiology, Shenyang General Hospital, Shenyang Military Area Command, Shenyang 110084, Liaoning, China)
关键词:
冠状动脉疾病; 急性冠脉综合征; 基因; 单核苷酸多态性
Keywords:
coronary disease;  acute coronary syndrome;  gene;  polymorphism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观察趋化因子白介素-8（Interleukin-8，IL-8)基因单核苷酸多态性与急性冠脉综合征（acute coronary syndrome,ACS）的相关性。方法： 采用直接测序的方法对675例ACS的患者和636例对照组进行检测，分析IL-8基因+394T/G单核苷酸多态的基因型和等位基因频率的分布情况。结果： IL-8基因+394 T/G单核苷酸多态在ACS组和对照组间的分布频率皆符合Hardy-Weinberg平衡定律，IL-8基因+394 T/G单核苷酸多态三种基因型（GG型，GT型和TT型）在ACS组分布频率分别为16.9%，48.7%和34.4%，在对照组分别为18.1%，50.9%和31.0%。IL-8基因+394 T/G多态基因型和等位基因频率在正常对照组和ACS组之间无明显的相关(P>0.05)。Logistic回归校正性别、年龄、体质量指数、吸烟、高血压病、高脂血症、糖尿病等冠心病易患因素后，IL-8基因+394 T/G多态与ACS的发病无相关关系。结论： 在中国北方汉族人群中IL-8基因+394T/G多态与ACS发病无相关关系，IL-8基因+394 T/G 多态不是ACS发病的独立危险因素。
Abstract:
AIM:To investigate the association between IL-8 +394T/G polymorphism and acute coronary syndrome (ACS) in a Han population in Northern China. METHODS: A case-control study was conducted in 675 patients with ACS and 636 controls with normal coronary angiograms. Polymorphic genotypes were determined by polymerase chain reaction and sequencing analysis. RESULTS: Genotype frequencies in IL-8 +394 T/G polymorphism were in good concordance with the Hardy-Weinberg equilibrium in both case and control groups. Genotype frequencies of GG, GT and TT of IL-8 +394 T/G polymorphism were 18.1%, 50.9% and 31.0% in the controls, and 16.9%, 48.7% and 34.4% in patients with ACS, respectively. There were no significant differences in the genotype and allele distribution of +394 T/G polymorphism of the IL-8 gene between groups (P>0.05). Logistic regression analysis with adjustments for other risk factors revealed that the IL-8 +394 T/G allele carriers did not significantly increase the risks of ACS compared with noncarriers (P>0.05). CONCLUSIONS: IL-8 +394 T/G polymorphism was not a genetic risk factor for ACS in a Han population in Northern China.

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备注/Memo

备注/Memo:
收稿日期：2011-11-27.基金项目：军队临床高新技术重大项目资助(2010GXJS001)，国家自然科学基金青年科学基金项目资助（81100135） 通讯作者：韩雅玲，主任医师，主要从事心血管病基础和临床研究Email：hanyl1976@hotmail.com 作者简介：张效林，硕士生Email：xiaolindianyu75@sina.com 共同第一作者：张保海，主治医师，博士生Email：zhangbaohai@163.com
更新日期/Last Update: 2012-07-20