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|本期目录/Table of Contents|

MK2基因与新疆维吾尔族女性三酰甘油的关联

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
456-460
栏目:
临床研究
出版日期:
2012-08-25

文章信息/Info

Title:
Relationship between MK2 and triglyceride in Xinjiang Uygur females
作者:
林 娜1; 姚晓光2; 王红梅2; 周 玲2; 李南方2
(1.新疆医科大学研究生院，新疆 乌鲁木齐830054；2.新疆维吾尔自治区人民医院高血压中心，新疆高血压研究所，新疆 乌鲁木齐 830001)
Author(s):
LIN Na1;  YAO Xiao-guang2;  WANG Hong-mei2;  ZHOU Ling2;  LI Nan-fang2
(1.College of Graduates, Xinjiang Medical University, Urumqi 830054, Xinjiang, China; 2.Center of Hypertension, People’s Hospital of Xinjiang Uygur Autonomous Region & Institute of Xinjing Hypertension, Urumqi 830001, Xinjiang, China)
关键词:
MK2基因; 遗传多态性; 维吾尔族; 女性; 三酰甘油
Keywords:
MK2 gene;  genetic polymorphism;  Uygur;  female;  triglycerides
分类号:
Q344.13
DOI:
-
文献标识码:
A
摘要:
目的:探讨MK2基因多态性与新疆和田地区维吾尔族女性三酰甘油（TG）的相关性。方法： 采用整群随机抽样方法抽取590个维吾尔族女性作为研究对象，检测其血脂水平以及肿瘤坏死因子-α（TNF-α），并在48例维吾尔族血脂异常人群中测序筛查MK2基因功能区的变异位点，选取代表性变异位点，应用TaqMan-PCR在大样本人群中进行基因型鉴定及病例-对照研究。结果： MK2基因rs44890位点CC、CT、TT 3种基因型及C、T等位基因在TG正常组、TG边缘异常组、TG升高组分布频率差异具有统计学意义（P=0.023和0.004）；rs44890的不同基因型间TG差异无统计学意义，但有逐渐减少的趋势（CC>CT>TT），同时还发现TNF-α在3种基因型间有逐渐减小的趋势（CC>CT>TT），但差异无统计学意义；显性模型中，rs44890位点CT+TT基因型与TT基因型TG差异具有统计学意义（CC>CT+TT，P=0.021）。维吾尔族女性人群中rs45514798不同基因型间TG水平差异均无统计学意义。结论： MK2基因rs45514798位点与新疆维吾尔族女性TG不相关，rs44890位点与维吾尔族女性TG的关系有待进一步研究。
Abstract:
AIM:To investigate the association of genetic polymorphisms of mitogen-activated protein kinase activated protein kinase 2 gene (MK2) with triglyceride (TG) in a female Xinjiang Uygur population. METHODS: A total of 595 Uygur females were randomly recruited from the Hetian area. Two single nucleotide polymorphisms (rs44890 and rs45514798) in MK2 gene were selected and genotyped by Taqman-PCR. All subjects underwent questionnaire, physical examination, and measurement of lipid levels and plasma TNF-α. RESULTS: The frequencies of genotypes CC, CT, TT and alleles C, T of the MK2 gene in the normal TG group, the edge of the abnormal group, and the high TG group were different. (P=0.023, 0.004). In Uygur females, no significant difference was found in the concentrations of TG and TNF-α in the three genotypes of rs44890, but a decreasing tendency was observed (CC>CT>TT). In the dominant model, TG was different between CC+CT and CT of rs44890 genotype (CC>CT+TT, P=0.021). None of the alleles and genotypes frequencies of rs45514798 were different in the three TG groups in Uygur females of Xinjiang. CONCLUSION: Our data showed a negative association of rs45514798 with TG in a female Uygur population from the Hetian area of Xinjiang, but the association of rs44890 with TG in Uygur females needs further study.

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备注/Memo

备注/Memo:
收稿日期：2012-02-17.基金项目：新疆维吾尔自治区重点实验室-新疆高血压病研究实验室基金资助（XJYS0906-2011-02） 通信作者：李南方，主任医师，主要从事高血压及相关疾病的研究Email:Lnanfang@yahoo.com.cn 作者简介：林娜，硕士生Email: linna0991@163.com
更新日期/Last Update: 2012-07-20