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|本期目录/Table of Contents|

冠心病患者肠道对尿酸代谢的活性分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
503-506
栏目:
临床研究
出版日期:
2012-08-25

文章信息/Info

Title:
Uricolysis of gut in patients with coronary heart disease
作者:
李林岭; 谢文光; 李 敏; 吕 湛
(川北医学院附属医院心血管内科，四川 南充 6370072)
Author(s):
LI Lin-ling;  XIE Wen-guang;  LI Min;  LV Zhan
(Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan, China)
关键词:
冠状动脉疾病; 大便; 尿酸分解
Keywords:
coronary disease;  feces;  uricolysis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨冠心病患者肠道对尿酸的清除作用，探讨该类患者血尿酸代谢异常的可能机制。方法： 入选符合纳入标准的正常对照组40例、冠心病患者30例（伴血尿酸增高者15例和血尿酸水平正常者15例），收集所有受试者相关的血液学指标，并用酶比色法在体外检测其大便中的尿酸含量。结果： 1 g大便内的细菌分解的尿酸量：血尿酸水平正常的冠心病患者显著高于正常对照（P<0.05）；伴血尿酸水平增高的冠心病患者亦高于正常对照但无统计学差异； 冠心病两亚组间相比没有统计学差异。血脂：冠心病患者的血三酰甘油显著高于正常人（P<0.05）；高密度脂蛋白胆固醇显著低于正常对照（P<0.01）。血清内的总胆红素：冠心病患者血清中总胆红素水平低于正常对照组（P<0.05）。结论： 冠心病患者的肠道对尿酸的代谢活性高于正常人，肠道在冠心病患者血尿酸的代谢异常中发挥着重要的作用，冠心病患者的抗氧化能力较正常人降低。
Abstract:
AIM:To evaluate uricolysis of gut in patients with coronary heart disease (CHD) and to discuss the underlying mechanisms for the disturbance of uric acid from the perspective of the gut. METHODS: A total of 70 subjects provided informed consent and were recruited into the study. Forty subjects were normal and 30 were subjects with established CHD (15 with elevated serum uric acid and 15 with normal level of serum uric acid). Enzyme colorimetric method was used to detect uric acid in feces, and routine laboratory indicators were recorded. All data were analyzed by SPSS v.13.0. RESULTS: Metabolized uric acid by flora in 1 g feces of patients with CHD with normal levels of serum uric acid was significantly higher than in normal subjects (P<0.05), and metabolized uric acid of patients with CHD with elevated serum uric acid was comparable to that of normal subjects. No statistical difference was seen between CHD subgroups. Triglycerides of patients with CHD were significantly higher and high-density lipoprotein cholesterol was lower than in normal subjects (P<0.05, P<0.01). Total serum bilirubin of patients with CHD was significantly lower than normal subjects (P<0.05). CONCLUSIONS: Uricolysis of gut in subjects with CHD is significantly higher than in normal subjects. The gut may partially contribute to the abnormal metabolism of uric acid in the pathogenesis of CHD. Anti-oxidative ability of patients with CHD is lower than in normal subjects.

参考文献/References

[1]Martinon F,Petrilli V,Mayor A,et al.Gout-associated uric acid crystals activate the NLRP3 inflammasome[J].Nature,2006,440(9):237-241.

[2]Tamariz L,Harzand A,Palacio A,et al.Uric acid as a predictor of all-cause mortality in heart failure:a meta-analysis[J].Congest Heart Fail, 2011,17(1):25-30.

[3]Feig DI,Kang DH,Johnson RJ.Uric acid and cardiovascular risk[J].N Engl J Med,2008,359(17):1811-1821.

[4]Kim SY,Guevara JP,Kim KM,et al.Hyperuricemia and coronary heart disease:a systematic review and meta-analysis[J].Arthritis Care Res,2010,62(2):170-180.

[5]Holme I,Aastveit AH,Hammar N,et al.Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein Mortality Risk Study (AMORIS)[J].Intern Med,2009,266(6):558-570.

[6]Benedict JD,Forsham PH,Stetten D Jr.The metabolism of uric acid in the normal and the gouty human studied with the aid of isotopic uric acid[J].J Biol Chem,1949,181(1):183-193.

[7]Buzard J,Bishop C,Talbott J.Recovery in humans of intravenously injected isotopic uric acid[J].J Biol Chem,1952,196(1):179-184.

[8]Sorensen LB.Degradation of uric acid in man[J].Metabolism,1959,8:687-703.

[9]Sorensen LB.Role of the intestinal tract in the elimination of uric acid[J].Arthritis Rheum,1965,8(5):694-706.

[10]Hellstrom I,Raycraft J,Hayden-Ledbetter M,et al.The HE4(WFDC2)protein is a biomarker for ovari-an carcinoma[J].Cancer Res,2003,63(13):3695-3700.

[11]So A,Thorens B.Uric acid transport and disease[J].J Clin Invest,2010,120(6):1791-1799.

[12]Gersch MS,Johnson RJ.Uric acid and the immune response[J].Nephrol Dial Transplant,2006,21(11):3046-3047.

[13]Spoon DB,Lerman A,Rule AD,et al.The association of serum uric acid levels with outcomes following percutaneous coronary intervention[J].J Interv Cardiol,2010,23(3):277-283.

[14]苏保鑫,李淑翠,王贵年,等.同型半胱氨酸和总胆红素及高敏C反应蛋白水平与冠心病临床分型相关性研究[J].中国医药,2009,12(4):968-970.

备注/Memo

备注/Memo:
收稿日期：2011-12-14.通讯作者：吕湛，教授，主要从事冠心病基础与临床研究Email：doctor_lz@163.com 作者简介：李林岭，住院医生，硕士生Email：anna917@126.com
更新日期/Last Update: 2012-07-20