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|本期目录/Table of Contents|

钙敏感受体及其配体在血管系统中的作用和机制的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
514-516，524
栏目:
综述
出版日期:
2012-08-25

文章信息/Info

Title:
Progress of calcium-sensing receptor and ligand in blood vessels
作者:
韩 磊; 迟锦玉; 尹新华
(哈尔滨医科大学附属第一医院心血管内科，黑龙江 哈尔滨 150001)
Author(s):
HAN Lei;  CHI Jin-Yu;  YIN Xin-hua
(Department of Cardiology, First Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
钙敏感受体; 配体; 拟钙剂; 细胞外钙; 血管
Keywords:
calcium-sensing receptor;  ligand;  calcimimetics;  extracellular calcium;  blood vessel
分类号:
R331.3
DOI:
-
文献标识码:
A
摘要:
近年来多项研究发现，钙敏感受体（CaSR）在血管系统中表达并发挥重要作用。本文就CaSR的结构、功能、配体的分类及其在血管系统中作用作一简要综述。
Abstract:
Recent studies have shown that the calcium-sensing receptor (CaSR) is expressed in blood vessels. This review summarizes the structure, functions and ligands of CaSR as well as its effects on blood vessels.

参考文献/References

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[3]Alam MU,Kirton JP,Wilkinson FL,et al.Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells[J].Cardiovasc Res,2009,81(2):260-268.

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[5]Rybczynska A,Jurska-Jasko A,Boblewski K,et al.Blockade of calcium channels and AT1 receptor prevents the hypertensive effect of calcilytic NPS 2143 in rats[J].J Physiol Pharmacol,2010,61(2):163-170.

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[7]Thakore P, Ho WS.Vascular actions of calcimimetics:role of Ca(2+)-sensing receptors versus Ca(2+) influx through L-type Ca(2+) channels[J].Br J Pharmacol,2011,162(3):749-762.

[8]Koleganova N,Piecha G, Ritz E,et al.A calcimimetic(R-568),but not calcitriol,prevents vascular remodeling in uremia[J].Kidney Int,2009,75(1):60-71.

[9]Kawata T,Nagano N,Obi M,et al.Cinacalcet suppresses calcification of the aorta and heart in uremic rats[J].Kidney Int,2008,74(10):1270-1277.

[10]Vizard TN,O'Keeffe GW,Gutierrez H,et al.Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor[J].Nat Neurosci,2008,11(3):285-291.

[11]Farzaneh-Far A,Proudfoot D,Weissberg PL,et al.Matrix Gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor[J].Biochem Biophys Res Commun,2000, 277(3):736-740.

[12]Harno E,Edwards G,Geraghty AR,et al.Evidence for the presence of GPRC6A receptors in rat mesenteric arteries[J].Cell Calcium,2008,44(2):210-219.

备注/Memo

备注/Memo:
收稿日期：2011-12-29.基金项目：高等学校博士学科点专项研究基金项目资助（200802260006）；国家自然科学基金项目资助（30872387） 通讯作者：尹新华，教授，主要从事免疫抑制剂引起的心肌损伤与钙敏感受体关系的研究 Email：harbin0910@yahoo.com 作者简介：韩磊，硕士生Email：chmds@126.com
更新日期/Last Update: 2012-07-20