微小RNA-缺血性心脏病治疗新的靶点
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2012年第4期
- 页码:
- 517-520
- 栏目:
- 综述
- 出版日期:
- 2012-08-25
文章信息/Info
- Title:
- miRNAs: A novel therapeutic target in ischemic heart disease
- Author(s):
- TU Ying-feng; WANG Xiao-yun; BU Li-hong; YAN Xue-feng; YANG Li-li; SHEN Bao-zhong
- (Molecular Imaging Center, Fourth Affiliated Hospital, Harbin Medical University, Harbin150001, Heilongjiang, China)
- Keywords:
- microRNA; ischemic heart disease; therapy
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 当前，缺血性心脏病（IHD）是世界主要死亡原因之一。IHD是指因冠状动脉不同程度的受阻引起冠状血流和心肌耗氧需求之间不平衡而导致的心肌损害，最终形成充血性心力衰竭。心脏缺血损伤后，非缺血部位的心肌出现心肌重构，如心肌间质纤维化和心肌肥厚。心肌的重构过程可使心脏功能进一步恶化，更容易诱发心律失常。微小RNA(microRNAs,miRNAs)是一类长约22个核苷酸的非编码小分子RNA，通过与靶蛋白 mRNA 3′端非编码区的不完全互补结合，抑制靶 mRNA 转录后的表达。最近大量研究显示，miRNA 在心脏病理、生理过程中发挥着重要的调控作用，尤其与心肌梗死和梗死后心脏重构的发生、发展密切相关。本文将从miRNAs在IHD中的调控作用进行阐述，并探讨以miRNAs为靶点改善IHD患者的临床转归。
- Abstract:
- Ischemic heart disease (IHD) is one of the leading causes of mortality worldwide. IHD is a form of congestive heart failure resulting from the imbalance between myocardial blood supply and oxygen demand, which is caused by different degrees of coronary artery obstruction. In response to the injury, nonischemic myocardium displays signs of secondary remodeling such as interstitial fibrosis and hypertrophy of cardiac myocytes. This remodeling process further deteriorates the pump function and increases susceptibility to arrhythmias. MicroRNAs (miRNAs) are small, noncoding RNAs that primarily function posttranscriptionally by interacting with the 3’untranslated region (UTR) of specific target mRNAs in a sequence-specific manner and regulate gene expression in a sequence-dependent manner. Recent research shows that miRNAs play important roles in the physiological and pathological processes of the heart, especially being involved in the occurrence and progress of myocardial infarction (MI) and post-MI remodeling. In this review we discuss how modulation of these miRNAs represents a promising new therapeutic strategy to improve the clinical outcome in IHD.
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备注/Memo
- 备注/Memo:
- 收稿日期：2012-03-02.作者简介: 涂应锋,博士生Email：tydoctor@163.com
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