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|本期目录/Table of Contents|

Rho激酶在心血管疾病中新进展及Rho激酶抑制剂的应用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
521-524
栏目:
综述
出版日期:
2012-08-25

文章信息/Info

Title:
Rho kinase in cardiovascular diseases and applications for Rho kinase inhibition: Current progress
作者:
刘春南; 余首先; 赵晓宇; 曹 妍 综述; 赵德超
(哈尔滨医科大学附属第一医院心血管内科八病房，黑龙江 哈尔滨 150001)
Author(s):
LIU Chun-nan;  YU Shou-xian;  ZHAO Xiao-yu;  CAO Yan;  ZHAO De-chao
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
抑制剂; Rho激酶; 心血管疾病
Keywords:
autophagy;  minhibition;  Rho kinase;  cardiovascular disease yocardial ischemia reperfusion injury;  Beclin 1;  mTOR
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
Rho激酶(ROCK)被认为是治疗心血管疾病的新靶点。本文主要简述RhoA/ROCK通路在调节脉管系统的功能，并探讨其在心血管疾病发病中的作用机制。
Abstract:
Rho kinase (ROCK) is regarded as a novel therapeutic target in the treatment of cardiovascular diseases. In this review we summarize the current understanding of the crucial role of the RhoA/ROCK pathway in the regulation of vascular functions and present its physiological and pathophysiological functions in cardiovascular diseases.autophagy.

参考文献/References

[1]Amano M,Nakayama M,Kaibuchi K. Rho-kinase/ROCK:a key regulator of the cytoskeleton and cell polarity[J].Cytoskeleton(Hoboken),2010,67(9):545-554.

[2]Dong M,Yan BP,Liao JK,et al.Rho-kinase inhibition:a novel therapeutic target for the treatment of cardiovascular diseases[J].Drug Discov Today,2010,15(15-16):622-629.

[3]Hahmann C,Schroeter T.Rho-kinase inhibitors as therapeutics:from pan inhibition to isoform selectivity[J].Cell Mol Life Sci,2010,67(2):171-177.

[4]Loirand G,Pacaud P.The role of rho protein signaling in hypertension[J].Nat Rev Cardiol, 2010,7(11):637-647.

[5]Miyamoto S,Del Re DP,Xiang SY,et al.Revisited and revised:is rhoA always a villain in cardiac pathophysiology?[J].Cardiovasc Transl Res,2010,3(4):330-343.

[6]Nunes KP,Rigsby CS,Webb RC.RhoA/rho-kinase andvascular diseases: what is the link?[J].Cell Mol Life Sci,2010,67(22):3823-3836.

[7]Pinner S,Sahai E.PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by rhoE[J].Nat Cell Biol,2008,10(2):127-137.

[8]Wang Y,Zheng XR,Riddick N,et al.ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells[J].Circ Res,2009,104(4):531-540.

[9]Shi J,Zhang YW,Yang Y,et al.ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice[J]. Mol Cell Cardiol,2010,49(5):819-828.

[10]Shi J,Zhang YW,Summers LJ,et al.Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy[J].Mol Cell Cardiol,2008,44(3):551-560.

[11]Haudek SB,Gupta D,Dewald O,et al.Rho-kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation[J].Cardiovasc Res,2009,83(3):511-518.

[12]Whitlock NA,Harrison B,Mixon T,et al.Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK[J].Ocul Pharmacol Ther,2009,25(3):187-194.

[13]Noma K,Rikitake Y,Oyama N,et al.ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury[J].Clin Invest, 2008,118(5):1632-1644.

[14]Lee DH,Shi J,Jeoung NH,et al.Targeted disruption of ROCK1 causes insulin resistance in vivo[J].Biol Chem,2009,284(18):11776-11780.

[15]Vemula S,Shi J,Hanneman P,et al.ROCK1functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability[J].Blood,2009,115(9):1785-1796.

[16]Ongusaha PP,Qi HH,Raj L,et al.Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage[J].Sci Signal,2008,1(47):ra14.

[17]Zhou Z,Meng Y,Asrar S,et al.A critical role of rho-kinase ROCK2 in the regulation of spine and synaptic function[J].Neuropharmacology,2009,56(1):81-89.

[18]Duffy P,Schmandke A,Schmandke A,et al. Rho-associated kinase II(ROCKII) limits axonal growth after trauma within the adult mouse spinal cord[J].J Neurosci,2009,29(48):15266-15276.

[19]Takagi Y,Yasuda S,Takahashi J,et al.Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest[J].Circ,2009,73(4):767,769.

[20]Shin HK,Salomone S,Potts EM,et al.Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms[J].Cereb Blood Flow Metab,2007,27(5):998-1009.

[21]Uehata M,Ishizaki T,Satoh H.Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension[J].Nature,1997,389(6654):990-994.

[22]Libby P,Ridker PM,Maseri A.Inflammation and atherosclerosis[J].Circulation,2002,105(9):1135-1143.

[23]Aukrust P,Halvorsen B,Yndestad A,et al.Chemokines and cardiovascular risk.Arterioscler[J].Thromb Vasc Biol,2008,28(11):1909-1919.

备注/Memo

备注/Memo:
收稿日期：2011-10-11.通讯作者：赵德超，副教授，主要从事心血管疾病的临床诊治研究 Email：zhaodechao616@yahoo.com.cn 作者简介：刘春南，硕士生Email：liuchunnan1984214@163.com
更新日期/Last Update: 2012-07-20