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|本期目录/Table of Contents|

自噬在心脏疾病中的保护作用及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
529-531，538
栏目:
综述
出版日期:
2012-08-25

文章信息/Info

Title:
Protection of autophagy in heart and clinical significance
作者:
赵 磊1; 吴瑞鑫1; 樊 荣1; 陈 迈2; 裴建明1
(第四军医大学：1.基础部生理学教研室，2.西京医院心内科，陕西 西安 710032)
Author(s):
ZHAO Lei1;  WU Rui-xin1;  FAN Rong1;  CHEN Mai2;  PEI Jian-ming1
(1.Department of Physiology, 2.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
自噬; 心脏疾病; 保护作用
Keywords:
autophagy;  heart disease;  protective role
分类号:
R392.3
DOI:
-
文献标识码:
A
摘要:
最近几年，心血管疾病的死亡率和致残率仍在上升，但是理想的治疗手段并没有跟上。研究人员已经把目光转移到了心血管疾病的信号通路的研究中，来寻找新的治疗靶点。其中一个重要的机制是细胞自噬，其对于细胞的正常生长很重要，同时也与一些疾病的发生有密切关系。总的来说，自噬是一把双刃剑。我们面临的最大挑战就是如何调控自噬来达到治疗的目的。
Abstract:
It is widely accepted that morbidity and mortality of heart diseases continues at a growing pace and novel therapies have fallen behind. In recent years, investigators have focused a great deal of attention to the signaling pathways involved in heart diseases, which may become the next novel therapeutic targets for heart disease. Autophagy, a double-edged sword, is essential for normal cell growth but is also involved in disease pathogenesis. The biggest challenge is how to appropriately regulate autophagy for therapeutic gains.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-01-15.基金项目：国家自然科学基金资助（30971060）；陕西省科学技术研究发展计划项目资助（S2010SF883 ） 通讯作者：樊荣，高级实验师，主要从事心脏内分泌研究Email：heartj@fmmu.edu.cn 共同通讯作者：陈迈，主治医师，主要从事心肌细胞损伤与修复研究Email:chenmai@fmmu.edu.cn 作者简介：赵磊，本科生 Email：yunzhongteng@vip.qq.com 共同第一作者：吴瑞鑫，本科生Email：972836619@qq.c
更新日期/Last Update: 2012-07-20