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|本期目录/Table of Contents|

心肾综合征病理生理机制的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
544-545，548
栏目:
综述
出版日期:
2012-08-25

文章信息/Info

Title:
Research progress in pathophysiological mechanism in cardiorenal syndrome
作者:
李腾飞 综述; 杜金行 审校
(卫生部中日友好医院中西医结合心内科，北京 100029)
Author(s):
LI Teng-fei;  DU Jin-hang
(Department of Cardiology, Integrative Medicine, China-Japan Friendship Hospital, Beijing 100029, China)
关键词:
心肾综合征; 病理生理学; 机制
Keywords:
cardiorenal syndromes;  pathophysiology;  mechanisms
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
传统的心肾综合征（CRS）指慢性心力衰竭引起的进行性肾功能损害、利尿剂抵抗和心脏容量负荷过重，最终导致心力衰竭恶化的一系列病理变化。随着研究的不断深入，CRS的定义范围得到大大扩展。CRS的发病机制复杂，至今尚未阐清，本文就近年CRS病理生理机制的研究进展进行了综述。
Abstract:
The traditional definition of cardiorenal syndrome (CRS) is a series of pathological changes when chronic failure causes progressive renal injury, diuretic resistance, heart volume overload and, finally, worsening of heart failure. With additional research, the definition range of CRS has been greatly extended. The pathogenesis of CRS is complex and still remains unclear. This review presents recent research progress in pathophysiological mechanisms for CRS.

参考文献/References

[1]Nohria A,Hasselblad V,Stebbins A,et al.Cardiorenal interactions: Insights from the ESCAPE trial[J].J Am Coll Cardiol,2008,51(13):1268-1274.

[2]Liu PP.Cardiorenal syndrome in heart failure:a cardiologist’s perspective[J].Can J Cardiol,2008,24(suppl B):25B-29B.

[3]Brown JR,Uber PA,Mehra MR.The progressive cardiorenal syndrome in heart failure: mechanisms and therapeutic insights[J].Curr Treat Options Cardiovasc Med,2008,10(4):342-348.

[4]Krum H,Schlaich M, Whitbourn R,et al.Catheter-based renal sympathetic denervation for resistant hypertension:a multicentre safety and proof-of-principle cohort study[J].Lancet,2009,373(9671):1275-1281.

[5]Mitchell MD,Laird RE,Brown RD,et al.IL-1beta stimulates rat cardiac fibroblast migration via MAP kinase pathways[J].Am J Physiol Heart C irc Physiol,2007,29(2):H1139-H1147.

[6]Silva RP,Barbosa PH,Kimura OS,et al.Prevalance of anemia and its association with cardio-renal syndrome[J].Int J Cardiol,2007,120(2):232-236.

[7]O’Meara E,Clayton T,McEntegart MB, et al.Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure-results of the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) program[J].Circulation,2006,113(7):986-994.

[8]Ronco C,Haapio M,House AA, et al.Cardiorenal syndrome[J].J Am Coll Cardiol,2008,52(19):1527-1539.

备注/Memo

备注/Memo:
收稿日期：2011-12-27.基金项目：国家自然科学基金项目资助（81072924）通讯作者：杜金行，教授，主要从事心肾交集性疾病基础和临床研究 Email:du7135@sina.com 作者简介：李腾飞，硕士生Email:litengfei1109@yahoo.cn
更新日期/Last Update: 2012-07-20