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|本期目录/Table of Contents|

干细胞的种类和特性研究及评价

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第5期
页码:
667-668
栏目:
综述
出版日期:
2012-10-25

文章信息/Info

Title:
Progress and evaluation of stem cell types and characteristics
作者:
刘 勇1; 刘怡辰2
(1.四川省自贡市第三人民医院心内科，四川 自贡 643020；
2.重庆医科大学09级临床医学系,重庆 401331)
Author(s):
LIU Yong1;  LIU Yi-cheng2
(1.Department of Cardiology, Zigong Third People’s Hospital, Zigong 643020, Sichuan, China; 2.Grade 2009, Department of Clinical Medicine, Chongqing Medical and Science University, Chongqing 401331, China)
关键词:
多能干细胞; 血管再生; 再生医学
Keywords:
multipotent stem cells;  vascular regeneration;  regenerative medicine
分类号:
R392.24
DOI:
-
文献标识码:
A
摘要:
目前从3种常见干细胞的特点看，仍会以成人干细胞的研究和使用为主。胚胎干细胞有望以脐血干细胞作为突破口，并将其储存保养作为个体成年后再生疗法的资源，而将来必将以批量化研究诱导全能干细胞的特性和应用，制造出人造组织、器官、血管等，成为再生医学可以信手拈来的材料。
Abstract:
In view of our present understanding of the three common stem cells, the main research area will continue to focus on the research and application of adult stem cells. Research on the storage and maintenance of embryonic stem cells following a breakthrough in research on umbilical cord blood stem cells can produce resources of individual adult regeneration. In the future, applications of induced pluripotent stem cells in batch will create artificial tissues, organs and blood vessels as useful materials for regenerative medicine.

参考文献/References

[1]Lowry WE,Richter L,Yachechko R,et al.Generation of human induced pluripotent stem cells from dermal fibroblasts[J].Proc Natl Acad Sci USA,2008,105(25):2883-2888.
[2]Meissner A,Wemig M.Jaenisch R.Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cejls[J].Nat Biotechno,2007,25(9):1177-1181.
[3]Park IH,Zhao R,West JA,et al.Reprogramming of human somatic cells to pluripotency with defined factors[J].Nature,2008,451(2):141-146.
[4]Okita K,Ichisaka T,Yamanaka S.Generation of germline-competent induced pluripotent stem cells[J].Nature,2007,448(3):313-317.
[5]Kalka C,Baumgartner I.Gene and stem cell therapy in peripheral arterial occlusive disease[J].Vasc Med,2008,13(2):157-172.
[6]Yu J,Vodyanik MA,Smuga-Otto K,et al.Induced pluripotent stem cell lines derived from human somatic cells[J].Science,2007,318(18):1917-1920.
[7]Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J].Cell,2007,131(8):861-872.
[8]Jujo K,Ii M,Losordo DW.Endothelial progenitor cells in neovascularization of infarcted myocardium[J].J Mol Cell Cardiol,2008,45(4):530-544.

备注/Memo

备注/Memo:
收稿日期：2011-12-15.
通讯作者：刘勇，教授，主要从事心脏病学、内科学和医学软 科学研究Email:liuyong620710@126.com
更新日期/Last Update: 2012-11-16