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急性冠脉综合征患者血清OPG、sRANKL、OPG/sRANKL比值与冠状动脉粥样硬化斑块稳定程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第6期
页码:
704-707
栏目:
临床研究
出版日期:
2012-12-25

文章信息/Info

Title:
Relationship between levels/ratios of serum osteoprotegerin and sRANKL and stabilization of coronary artery atherosclerosis in patients with acute coronary syndrome
作者:
罗助荣; 林 毅; 章文莉; 郑卫星; 盖晓波
(南京军区福州总医院心内科、厦门大学附属东方医院，福建 福州 350025)
Author(s):
LUO Zhu-rong;  LIN Yi;  ZHANG Wen-li;  ZHENG Wei-xing;  GAI Xiao-bo
(Department of Cardiology, Fuzhou PLA General Hospital, Nanjing Military Area Command & Oriental Hospital, Xiamen University, Fuzhou 350025, Fujian, China)
关键词:
急性冠脉综合征; 系统; 骨保护素
Keywords:
acute coronary syndromes;  osteoprotegerin;  soluble receptor activator of nuclear factor;  coronary artery disease stabilization
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨急性冠脉综合征（ACS）患者血清骨保护素（osteoprotegerin,OPG）及其配体（souble-RANKL，sRANKL）和OPG/sRANKL比值与冠状动脉粥样硬化稳定程度的相关性。方法： 纳入研究者分成3组：ACS患者（335例）、稳定型心绞痛（SAP）患者（120例）与正常对照组（120例）。其中ACS组又分为不稳定心绞痛（UAP组）134例，非ST段抬高型心肌梗死（NSTEMI组）80例以及ST段抬高型心肌梗死（STEMI）组121例3组。通过ELISA检测其血清OPG和sRANKL水平，并将二者血清水平及比值（OPG/sRANKL）与ACS冠状动脉粥样硬化斑块稳定程度进行比较分析。结果： ACS、SAP及对照组3组间血清OPG、sRANKL、OPG/sRANKL比值均有显著差异（均P<0.01）。 ACS组内3组血清OPG、sRANKL、OPG/sRANKL比值也均有显著差异（均P<0.05）,其中STEMI组与UAP组有显著差异（P<0.05），UAP组与NSTEMI组、NSTEMI与STEMI组间无显著差异。 冠脉Gensini积分与血清OPG水平呈正相关（r=0.252，P<0.01），与OPG/sRANKL呈正相关（r=0.284，P<0.01），与血清sRANKL水平呈负相关（r=-0.235，P<0.05）。结论： 血清OPG、sRANKL、OPG/sRANK比值与ACS病情及冠状动脉粥样硬化斑块稳定程度有关联。
Abstract:
AIM:To analyze the relationship between the osteoprotegerin (OPG) system and stabilization of coronary artery atherosclerosis in patients with acute coronary syndrome (ACS). METHODS: A total of 575 consecutive patients were divided into three groups: ACS group (n=335), stable angina (SA) group (n=120) and control group (n=120). ACS group was subdivided into unstable angina (UA) group of 134 patients, non-ST-segment elevation myocardial infarction (NSTMI) group of 80 patients and ST-segment elevation myocardial infarction (STMI) group of 121 patients. Serum OPG and its ligand (souble-RANKL, sRANKL) levels were measured by enzyme-linked immunosorbent assay (ELISA). The relationship between levels of OPG and sRANKL as well as the ratio of the two (OPG/sRANKL) and stabilization of coronary artery atherosclerosis was investigated. RESULTS: Serum OPG, sRANKL, and OPG/sRANKL ratios were different between ACS, SA and control groups (P<0.01). Serum OPG, sRANKL and OPG/sRANKL ratios were different among the three subgroups of ACS group (P<0.05). The difference between STMI group and UA group was significant (P<0.05). The difference between UA group and NSTMI group and the difference between NSTMI group and STMI group were not significant. Gensini coronary points were positively correlated with both serum OPG levels (r=0.252, P<0.01) and OPG/sRANKL (r=-0.284, P<0.01), but negatively correlated with serum sRANKL levels (r=-0.235, P<0.05). CONCLUSION: OPG and sRANKL levels and the ratio of the two (OPG/sRANKL) are associated with the stabilization of coronary artery atherosclerosis in patients with ACS.

参考文献/References

[1]徐高阳,罗助荣.骨保护素系统和动脉粥样硬化的关系[J].中国动脉硬化杂志,2010,18(12):1004-1007.
[2]Crisafulli A,Micari A,Altavilla D,et al.Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction[J].Clin Sci(Lond),2005,109(4):389-395.
[3]Schoppet M,Schaefer JR,Hofbauer LC,et al.Low serum levels of soluble RANK ligand are associated with the presence of coronary artery disease in men[J].Circulation,2003,107(11):76-80
[4]Gensini CG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606-606.
[5]谢钦菁,罗助荣.骨保护素作为预测心血管疾病发病率和死亡率的新标志物的研究进展[J].中华临床医师杂志,2011,5(10):2963-2966.
[6]Sandberg WJ, Yndestad A,Qie E,et al.Enhanced T-cell expression of RANK ligand in acute coronary syndrome:possible role in plaque destabilization[J].Arterioscler Thromb Vasc Biol,2006,26(4):857-863.
[7]Ohmori R,Momiyama Y,Taniguchi H,et al.Association between steoprotegerin gene polymorphism and coronary artery disease in Japanese men[J].Atherosclerosis,2006,187(1):215-217.
[8]Schoppet M,Sattler AM,Schaefer JR,et al.Increased osteoprotegerin serum levels in men with coronary artery disease[J].Clin Endocrinol Metab,2003,88(3):1024-1028.
[9]Sandberg WJ, Yndestad A,Qie E,et al.Enhanced T-cell expression of RANK ligand in acute coronary syndrome:possible role in plaque destabilization[J].Arterioscler Thromb Vasc Biol,2006,26(4):857-863.
[10]Omland T,Ueland T,Jansson AM,et al.Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes[J].J Am Coll Cardiol,2008,51(6):627-633.

备注/Memo

备注/Memo:
收稿日期：2012-04-08.基金项目：军队医学科技创新项目资助（09MA094） 作者简介：罗助荣，主任医师 Email:mdlzrong@126.com
更新日期/Last Update: 2012-12-30