我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

外周血核因子-κB及sFas/sFasL活性与心力衰竭严重程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第6期
页码:
712-714,718
栏目:
临床研究
出版日期:
2012-12-25

文章信息/Info

Title:
Relationship between nuclear factor-κB activation and sFas/sFasL concentration in patients with congestive heart failure
作者:
杨丽霞; 吕晋琳; 齐 峰; 郭瑞威; 叶金善; 王先梅
(成都军区昆明总医院心血管内科，云南 昆明 650032)
Author(s):
YANG Li-xia;  Lv Jin-lin;  QI Feng;  GUO Rui-wei;  YE Jin-shan;  WANG Xian-mei
(Department of Cardiology, PLA Kunming General Hospital, Kunming 650032, Yunnan, China)
关键词:
心力衰竭; 核因子-κB; sFas; sFasL
Keywords:
congestive heart failure;  nuclear factor-κB;  sFas;  sFasL
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:探讨充血性心力衰竭(CHF)患者外周血单个核细胞(PBMCs)核因子-κB(NF-κB) 和血浆sFas/sFasL活性变化的意义。方法： 采用ELISA法检测76例CHF患者和30例对照组PBMCs的核蛋白提取物NF-κB和血浆sFas/sFasL的活性,并与患者心功能及超声心动图参数相比较，分析其与心功能及心肌重构的关系。结果: CHF患者PBMCs中NF-κB及血浆sFas/sFasL活性高于对照组，二者与心脏收缩功能相关指标呈显著负相关，与心肌重构相关指标呈显著正相关，并且NF-κB的活化与sFas/sFasL水平呈正相关(P<0.05)。结论: CHF患者NF-κB及sFas/sFasL活性明显增高, 并与心功能恶化及心肌重构程度密切相关。
Abstract:
AIM:To investigate the relationship between nuclear factor-κB activation and sFas/sFasL on perpherial blood mononuclear cells in patients with congestive heart failure (CHF). METHODS: Seventy-six patients with CHF and 30 age- and gender-matched healthy subjects were included in the study. Concentrations of sFas/sFasL and activity of NF-κB on peripheral blood mononuclear cells were measured using ELISA assay and were compared with the echocardiographic parameters and cardiac function indexes. RESULTS: Concentrations of sFas/sFasL and NF-κB activity on peripheral blood mononuclear cells in CHF patients were higher than those in control group and in CHF patients. They were negatively correlated with cardiac function indexes but positively correlated with heart remodeling indexes. The activation level of NF-κΒ was positively correlated with the concentrations of sFas/sFasL (P<0.05). CONCLUSION: The concentrations of sFas/sFasL and the activity of NF-κB increase in CHF patients and can be used as markers of the development of heart remodeling and heart function failure.

参考文献/References

[1]Ibe W,Saraste A,Lindemann S,et al.Cardiomyocyte apoptosis is related to left ventricular Cardiomyocyte apoptosis is related to left ventricular dysfunction and remodelling in dilated cardiomyopathy, but is not affected by growth hormone treatment[J].Heart Fail,2007,9(2):160-167.
[2]Nadzhafipur R,Dolgov VV,Orlova OV,et al.Markers of Fas-mediated apoptosis in patients with heart failure[J].Klin Lab Diagn,2007,(10):19-20.
[3]Khoynezhad A,Jalali Z,Tortolani AJ,et al.A synopsis of research in cardiac apoptosis and its application to congestive heart failure[J].Tex Heart Inst,2007,34(3):352-359.
[4]Setsuta K,Seino Y,Ogawa T,et al.Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system[J].Circ,2004,68(8):747-750.
[5]郭瑞威,杨丽霞.核因子-κB在心力衰竭治疗中的研究进展[J].心血管病学进展,2005,26(3):288-290.
[6]Okamoto T,Sakurada S,Yang JP,et al.Regulation of NF-kappa B and disease control:identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-kappa B activation[J].Curr Top Cell Regul,1997,35:149-161.
[7]Starace D,Riccioli A,D'Alessio A,et al.Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB[J].FASEB J,2005,19(3):473-475.
[8]Blanco-Colio LM,Martin-Ventura JL,De Teresa E,et al.Increased soluble Fas plasma levels in subject at high cardiovascular risk; Atorvastain on inflammatory markers(AMI) study, astbstudy of ACTFAST[J].Arterioscler Thromb Vasc Biol,2007,27(1):168-174.

备注/Memo

备注/Memo:
收稿日期：2012-04-10.作者简介：杨丽霞，主任医师，博士 Email:doctorylixia@yahoo.com.cn
更新日期/Last Update: 2012-12-30