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|本期目录/Table of Contents|

铜川市老年非瓣膜病心房颤动患者脑栓塞的危险因素

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第6期
页码:
757-759
栏目:
临床研究
出版日期:
2012-12-25

文章信息/Info

Title:
Risk factors of cerebral embolism of elderly patients with nonvalvular atrial fibrillation in Tongchuan city
作者:
王成凯1; 宋昌鹏1; 朱晓娜2
(1.铜川市人民医院内一科，陕西 铜川 727000；2.陕西中医学院附属医院神经内科，陕西 咸阳 712000)
Author(s):
WANG Cheng-kai1;  SONG Chang-peng1;  ZHU Xiao-na2
(1.Department of Internal Medicine No 1, Tongchuan People's Hospital, Tongchuan 727000, Shaanxi, China; 2.Department of Neurology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi, China)
关键词:
心房纤颤; 脑栓塞; 危险因素; 病例对照研究
Keywords:
atrial fibrillation;  cerebral embolism;  risk factors;  case-control study
分类号:
R541.75；R743.33
DOI:
-
文献标识码:
A
摘要:
目的:调查铜川市老年非瓣膜病心房颤动(nonvalvular atrial fibrillation,NVAF)患者脑栓塞(cerebral embolism,CE)的危险因素。方法： 铜川地区非瓣膜病心房纤颤发生脑卒中确诊病例309例，进行1∶1配对进行病例对照研究，获得环境暴露等资料，采用EPI-info（6.04）和SPSS（15.0）统计软件进行单因素和多因素Logistic回归分析，计算各因素的调整比值比（OR）和95%可信限（CI）。结果： 单因素分析发现，老年NVAF患者并发高血压病、糖尿病、心力衰竭、短暂性脑缺血发作（TIA）、肥胖、吸烟、酗酒、高同型半胱氨酸血症等与CE成正相关，而抗凝治疗能降低患CE的危险。多因素分析结果显示，高血压病、糖尿病、TIA、高同型半胱氨酸血症是CE的独立危险因素。结论： 铜川市NVAF患者发生CE的独立危险因素是高血压病、糖尿病、TIA和高同型半胱氨酸血症，抗凝治疗是其保护因素。
Abstract:
AIM:To investigate elderly patients in Tongchuan city with nonvalvular atrial fibrillation (NVAF) with cerebral embolism (CE) as a risk factor. METHODS: In Tongchuan city, there were 309 confirmed cases of males and females with nonvalvular atrial fibrillation stroke. This was a 1∶1 matched case-control study using environmental exposure data with EPI-info (6.04) and SPSS (15) statistical software for uni- and multivariate logistic regression analysis and the calculation of each factor as adjusted odds ratio (OR) and 95% confidence limit (CI). RESULTS: Single factor analysis revealed that elderly NVAF patients with complications of hypertension, diabetes, heart failure, transient ischemic attack (TIA), obesity, smoking, alcoholism, high homocysteine, and CE were positively correlated, and that anticoagulation therapy may reduce the risk of CE. Multiple factor analysis showed hypertension, diabetes, TIA, and hyperhomocysteinemia as risk factors of CE. CONCLUSION: NVAF patients from Tongchuan city with CE have independent risk factors of hypertension, diabetes mellitus, TIA and hyperhomocysteinemia, and anticoagulant therapy is a protective factor.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-05-22.作者简介：王成凯，主治医师，硕士 Email:wangchengkai7937@126.com
更新日期/Last Update: 2012-12-30