心型脂肪酸结合蛋白在急性冠脉综合征中的临床应用
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2012年第6期
- 页码:
- 763-766
- 栏目:
- 综述
- 出版日期:
- 2012-12-25
文章信息/Info
- Title:
- Clinical application of heart type fatty acid-binding protein in acute coronary syndrome
- Author(s):
- ZHOU Bin; WEI Qing-min
- (Department of Cardiology, Xingtai People’s Hospital, Hebei Province, Xingtai 054031, Hebei, China)
- Keywords:
- heart type fatty acid-binding protein; acute coronary syndrome; myocardial markers; clinical application
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 心型脂肪酸结合蛋白是近几年国内外研究较多的一种新型心脏生化标志物，其心肌特异性强，在心肌细胞受损后可早期快速大量释放入外周血中，对于急性心肌损伤的早期诊断及预后判断均有很大的临床意义。本文就心型脂肪酸结合蛋白在急性冠脉综合征中的临床应用前景做一综述。
- Abstract:
- Heart type fatty acid-binding protein (H-FABP) is a new heart biochemical marker, which in recent years has been studied more in China and abroad. H-FABP has a high degree of myocardium specificity and can be rapidly released largely into the peripheral blood in the early stage after myocardial cell damage. This characteristic of H-FABP has important clinical significance for early diagnosis and prognosis of acute myocardial injury. The review summarizes the clinical application prospects of H-FABP in acute coronary syndrome.
参考文献/References
[1]Thygesen K,Alpert JS,White HD,et al.Universal definition of myocardial infarction[J].Circulation, 2007,116(22):2634-2653.[2]Niizeki T,Takeishi Y,Takabatake N,et al.Circulating levels of heart-type fatty acid-binding protein in a general Japanese population: effects of age, gender, and physiologic characteristics[J].Circ J,2007,71(9):1452-1457.[3]Lippi G,Schena F,Montagnana M,et al.Influence of acute physical exercise on emerging muscular biomarkers[J].Clin Chem Lab Med, 2008,46(9):1313-1318.[4]Bathia DP,Carless DR,Viswanathan K,et al.Serum 99th centile values for two heart-type fatty acid binding protein assays[J].Ann Clin Biochem,2009,46 (Pt 6):464-467.[5]Kim KS,Lee HJ,Kim K,et al.Heart-type fatty acid binding protein as an adjunct to cardiac troponin-I for the diagnosis of myocardial infarction[J].J Korean Med Sci,2011,26(1):47-52.[6]Body R,McDowell G,Carley S,et al.A FABP-ulous‘rule out’strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction[J].Resuscitation,2011,82(8):1041-1046.[7]McCann CJ,Glover BM,Menown IB,et al.Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T[J].Eur Heart J,2008,29(23):2843-2850.[8]Kim Y,Kim H,Kim SY,et al.Automated heart-type fatty acid-binding protein assay for the early diagnosis of acute myocardial infarction[J].Am J Clin Pathol,2010,134(1):157-162.[9]Bruins Slot MH,Reitsma JB,Rutten FH,et al.Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: a systematic review and meta-analysis[J].Heart,2010,96(24):1957-1963.[10]Kilcullen N,Viswanathan K,Das R,et al.Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin valuesJ[J].J Am Coll Cardiol,2007, 50(21):2061-2067.[11]McCann CJ,Glover BM,Menown IB,et al.Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain[J].Am J Cardiol,2009,103(1):22-28.[12]Viswanathan K,Kilcullen N,Morrell C,et al.Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative[J].J Am Coll Cardiol,2010,55(23):2590-2598.[13]管耘园,郭江宏,马明军.支架置入患者心型脂肪酸结合蛋白与左心室舒张早期/晚期速度峰值比值的关系[J].疑难病杂志,2007,6(9):518-520.[14]胡大一.不稳定型心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-303.[15]李洁琪,何成毓,李晓翔,等.心型脂肪酸结合蛋白和缺血修饰白蛋白在UAP危险分层中的诊断价值[J].山东医药,2010,50(21):21-22.
备注/Memo
- 备注/Memo:
- 收稿日期：2012-07-11.基金项目：河北省科技支撑计划项目资助（11276103D-79） 通讯作者：魏庆民，主任医师，主要从事心血管介入方面的研究 Email:weiqingmin@medmail.com.cn 作者简介：周彬，硕士生 Email:zhoubin_cardio@163.com
常用功能
统计/Statistics
- 摘要浏览/Viewed1253
- 评论/Comments
