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|本期目录/Table of Contents|

早发冠心病并发高血压病患者血浆结合珠蛋白水平与冠状动脉病变程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第1期
页码:
70-072
栏目:
临床研究
出版日期:
2013-02-25

文章信息/Info

Title:
Clinical significance of plasma haptoglobin levels in patients with premature coronary heart disease with essential hypertension
作者:
赵 琛1; 王述琦1; 王云英2; 范 茜1; 刘 萍1; 潘巍巍1; 张七一3
(青岛市市立医院:1.干部保健科，2.中心实验室，3.心内科，山东 青岛 266011)
Author(s):
ZHAO Chen1;  WANG Shuqi1;  WANG Yungying2;  FAN Qian1;  LIIUPing1;  PAN Weiwei1;  ZHANG Qiyi3
(1.Department of Health Care, 2.Central Lab, 3.Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China) )
关键词:
冠状动脉疾病; 结合珠蛋白; 高血压; 原发性
Keywords:
coronary disease;  haptoglobin;  essential hypertension
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:分析早发冠心病并发高血压病患者血浆结合珠蛋白（haptoglobin,Hp）水平的变化及其与冠状动脉病变严重程度的相关性。方法： 经冠脉造影确诊的早发冠心病患者90例，非冠心病的健康体检者90例作为对照组，据血压水平分类将90例早发冠心病患者分为3个亚组：正常血压及正常高值亚组（亚组1）、Ⅰ级和Ⅱ级高血压亚组（亚组2）、Ⅲ级高血压亚组（亚组3）。检测血浆Hp浓度，比较冠心病组与对照组血浆Hp浓度的差异；分析早发冠心病不同临床亚组间血浆Hp浓度、Gensini积分的差异及分析二者的相关性。结果： 早发冠心病组的血浆Hp浓度明显高于对照组，比较有统计学差异（P<001）。早发冠心病组3个亚组的Hp血浆浓度分别为（16±05） μg/L、（17±04） μg/L和（20±06） μg/L，3组之间差异有统计学意义（P<005）。两两比较，亚组3的Hp血浆浓度高于亚组1和亚组2，差别有统计学意义（均P<005）。3个亚组Gensini积分分别为（32±19）、（33±18）和（48±28），3亚组之间差异有统计学意义（P<005）。两两比较，亚组3的Gensini积分高于亚组1和亚组2，差别有统计学意义（均P<005），而亚组1与亚组2的Hp浓度和Gensini积分均无显著差异。结论： Hp水平的升高与早发冠心病的发生及冠脉狭窄的严重程度有关。
Abstract:
AIM:To investigate the clinical significance of the variations of blood plasma haptoglobin (Hp) in premature coronary heart disease (PCAD) patients with essential hypertension and to study the clinical correlations between the level of plasma Hp and PACDessential hypertension. METHODS: Ninety patients with PACD confirmed by coronary angiography were enrolled in this study and 90 healthy subjects were selected as control. According to the levels of blood pressure (Bp), the patients were divided into three groups: normal Bp group, Grade 1 Bp and Grade 2 group, and Grade 3 Bp group. Plasma levels of Hp were detected, plasma Hp levels between PACD groups and control group were compared and plasma Hp levels and Gensini scores and their correlation were analyzed in the three groups. RESULTS: Plasma levels of Hp in patients with PACD were significantly higher than the levels in control subjects (P<005). Plasma levels of Hp in the three PACD groups were (16±05) ng/ml, (17±04) ng/ml and (20±06) ng/ml, respectively, with significant differences among the three groups (P<005). Gensini scores in the three PACD groups were 32±19, 33±18 and 48±28, respectively, with significant difference among the three groups (P<005). The plasma level of Hp and Gensini score in Grade 3 group was higher than the level in the other two groups (P<005). CONCLUSION: Plasma Hp level has some clinical significance for diagnosis of PACD and assessment of degree of coronary stenosis along with its correlation with the development and advancement of PACD and with the degree of coronary stenosis.

参考文献/References

[1]中华心血管病杂志编辑部血脂异常对策专题委员会.血脂异常防治建议[J].中华心血管病杂志,1997,25(3):169-175.

[2]Kristiansen M,Graversen JH,Jacobsen C,et al.Identification of the hemoglobin scavenger receptor[J].Nature,2001,409(6817):198-201.

[3]Wassell J.Haptoglobin:function and polymorphism[J].Clin Lab,2000,46(11-12):547-552.

[4]Gensini GG.A more meaningful scoring system for determining the Severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.

[5]Langlois MR,Delanghe JR.Biological and clinical significance of haptoglobin polymorphism in humans[J].Clin Chem,1996,42(10):1589-1600.

[6]Maes M,Ruckoanich P,Chang YS,et al.Multiple aberrations in shared infammatory and oxidative and nitrosative stress(IO and NS) pathways explain the coassociation of depression and cardiovascular sorder(CVD),and the increased risk for CVD and due mortality in depressed patients[J].ProgNeuropsyehopharmacol Biol Psychiatry,2011,35(3):769-783.

[7]Blum S,Asaf R,Guetta J,et al.Haptoglobin genotype determines myocardia infarct size in diabetiet mice[J].J Am Coil Cardiol,2007,49(1):82-87.

[8]陈 丽,韩雅玲,荆全民,等.高血压与冠状动脉狭窄程度的相关性研究[J].解放军医学杂志,2011,36(4):327-330.

[9]Verma S,Anderson TJ. Fundamentals of endothelial function for the clinical cardiologist[J].Am Heart Association,2002,105(5):546-549.

[10]闫奎坡,王 滢.高血压与冠心病的关系研究进展[J].亚太传统医药,2009,5(6):140-141.

备注/Memo

备注/Memo:
收稿日期：2012-07-31.基金项目：青岛市科研基金资助(2008014) 通讯作者：张七一，主任医师，主要从事高血压和顽固性心律失常研究Email：zqy@public.qd.sd.cn 作者简介：赵琛，副主任医师，硕士生Email：zhaochen_0107@sina.com
更新日期/Last Update: 2013-03-20