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|本期目录/Table of Contents|

新的血管活性肽alarin的研究现状

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第1期
页码:
93-095
栏目:
综述
出版日期:
2013-02-25

文章信息/Info

Title:
Progress in alarin, a new biologically active peptide
作者:
崔 艳1; 高 丽1; 王跃民2
（第四军医大学：1.护理系临床护理学教研室，2.生理学教研室，陕西 西安 710032）
Author(s):
CUI Yan1;  GAO Li1;  WANG Yuemin2
(1.Department of Clinical Nursing, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
Alarin; 血管活性肽; 心血管系统
Keywords:
alarin;  biologically active peptide;  cardiovascular system
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
Alarin是一种最新发现的促生长激素神经肽（galanin）家族中的新成员，目前关于其详细功能和机制的研究非常缺乏。有研究表明，alarin可分布在皮肤血管平滑肌中，仅知晓其作用有抗水肿、收缩血管和降低皮肤血流量等，表明其可能在治疗水肿和休克等疾病方面有一定的临床应用前景。有关其在心血管系统的其他研究资料迄今尚未见任何报道。鉴于alarin是一种强效的血管活性物质，提示其可能对心血管系统具有重要的调节作用。
Abstract:
Alarin is a newly discovered member of the galanin family. Until now there have been few studies conducted on its specific functions and mechanism. Some studies have shown that alarin is distributed in the cutaneous vascular smooth muscles and plays roles in antiedema, blood vessel constriction and skin blood flow reduction. Alarin can be used in the treatment of edema and shock diseases. However, there have been no reports on alarin in relation to the cardiovascular system. Given that alarin is a potent vasoactive substance, it may play some important roles in the regulation of the cardiovascular system.

参考文献/References

[1]Santic R,Fenninger K,Graf K,et al.Gangliocytes in neuroblastic tumors express Alarin,a novel peptide derived by differential splicing of the galaninlike peptide gene[J].J Mol Neurosci,2006, 29(2):145-152.

[2]Santic R,Schmidhuber SM,Lang R,et al.Alarin is a vasoactive peptide[J]. Proc Natl Acad Sci USA,2007,104(24):10217-10222.

[3]Van Der Kolk N,Madison FN,Mohr M,et al.Alarin stimulates food intake in male rats and LH secretion in castrated male rats[J].Neuropeptides,2010,44(4):333-340.

[4]Lang R,Gundlach AL,Kofler B.The galanin peptide family:receptor pharmacology, pleiotropic biological actions, and implications in health and disease[J].Pharmacol Ther,2007,115(2):177-207.

[5]Bauer JW,Lang R,Jakab M,et al.Galanin family of peptides in skin function[J].Cell Mol Life Sci, 2008, 65(12):1820-1825.

[6]Fraley GS,Leathley E,Lundy N,et al.Effects of alarin on food intake, body weight and luteinizing hormone secretion in male mice[J].Neuropeptides,2012,46(2):99-104.

[7]Ewert TJ,Gritman KR,Bader M,et al.Postinfarct cardiac sympathetic hyperactivity regulates galanin expression[J].Neurosci Lett,2008,436(2):163-166.

[8]滕 旭,齐永芬.Alarin新的血管活性肽[J].生理科学进展,2007, 38(4):294.

[9]Robertson CR,Scholl EA,Pruess TH,et al.Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery[J].J Med Chem,2010,53(4):1871-1875.

[10]Kanazawa T,Misawa K,Carey TE.Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma[J].Expert Opin Ther Targets,2010,14(3):289-302.

[11]Jin WY,Liu Z,Liu D,et al.Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors[J].Brain Res,2010,1320:16-21.

[12]Lawrence CB.Galanin like peptide modulates energy balance by affecting inflammatory mediators?[J].Physiol Behav,2009,97(5):515-519.

[13]Kanazawa T,Misawa K,Carey TE.Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma[J].Expert Opin Ther Targets,2010,14(3):289-302.

[14]Pope RJ,Holmes FE,Kerr NC,et al.Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice[J].Mol Pain,2010,6:67.

[15]Karatayev O,Baylan J,Leibowitz SF.Increased intake of ethanol and dietary fat in galanin verexpressing mice[J].Alcohol,2009,43(8):571-580.

[16]Suzuki H,Onaka T,Dayanithi G,et al.Pathophysiological roles of galaninlike peptide in the hypothalamus and posterior pituitary gland[J].Pathophysiology,2009,6(4):217-224.

[17]Bertram L,Tanzi RE.Genome wide association studies in Alzheimer's disease[J].Hum Mol Genet,2009,18(R2):R137-R145.

[18]Counts SE,He B,Che S,et al.galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer’s disease[J].J Alzheimers Dis,2009,18(4):885-896.

[19]Santic R,Fenninger K,Graf K,et al.Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galaninlike peptide gene[J].J Mol Neurosci,2006,29(2):145-152.

[20]Wraith DC,Pope R,Butzkueven H,et al.A role for galanin in human and experimental inflammatory demyelination[J].Proc Natl Acad Sci USA,2009,106(36):166-171.

[21]Lutz EM,Ronaldson E,Shaw P,et al.Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells:consequences for signaling by VIP and PACAP[J].Mol Cell Neurosci,2006,31(2):193-209.

[22]Picciotto MR,Brabant C,Einstein EB,et al.Effects of galanin on monoaminergic systems and HPA axis:Potential mechanisms underlying the effects of galanin on addiction and stress related behaviors[J].Brain Res,2010,1314:206-218.

[23]Bauer JW,Lang R,Jakab M,et al.Galanin family of peptides in skin function[J].Cell Mol Life Sci,2008,65(12):1820-1825.

[24]Schmidhuber SM,Santic R,Tam CW,et al.Galanin like peptides exert potent vasoactive functions in vivo[J].J Invest Dermatol,2007,127(3):716-721.

[25]ilaPorcile E,Xu ZQ,Mailly P,et al.Dendritic synthesis and release of the neuropeptide galanin:morphological evidence from studies on rat locus coeruleus neurons[J].J Comp Neurol,2009,516(3):199-212.

备注/Memo

备注/Memo:
收稿日期：2012-04-09.基金项目：国家自然科学基金项目资助(31200875) 通讯作者：王跃民，高级实验师，主要从事心血管生理学研究Emai：ymwang@fmmu.edu.cn 作者简介：崔艳，副教授，博士Emai：cuiyan@fmmu.edu.cn
更新日期/Last Update: 2013-03-20