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|本期目录/Table of Contents|

原发性高血压患者血清脂联素水平与IL-6的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第2期
页码:
211-212223
栏目:
临床研究
出版日期:
2013-04-25

文章信息/Info

Title:
Relationship between adiponectin and interleukin-6 in patients with essential hypertension
作者:
曹世平1; 刘 俭1; 崔 凯1; 王月刚1; 王 鹏1; 侯玉清1; 张 犁2
(南方医科大学：1.南方医院心内科，2.基础医学实验中心，广东 广州 510515)
Author(s):
CAO Shi-ping1;  LIU Jian1;  CUI Kai1;  WANG Yue-gang1;  WANG Peng1;  HOU Yu-qing1;  ZHANG Li2
(1.Department of Cardiology, 2.Teaching Center of Experimental Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China)
关键词:
高血压; 原发性; 脂联素; 白细胞介素-6
Keywords:
essential hypertension;  adiponectin;  interleukin-6
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的:探讨高血压患者血清脂联素(adiponectin，APN)水平，以及APN与白细胞介素-6(interlectin-6，IL-6)的相关性。方法： 选取原发性高血压患者60例(HT组，其中高血压Ⅰ级、Ⅱ级和Ⅲ级患者分别为20例)，健康对照者20例(Control组)，采用酶联免疫吸附法测定两组患者血清APN水平和IL-6水平。结果： 高血压患者血清APN水平［(8.2±3.8) mg/L］显著低于健康对照组［(10.4±2.9) mg/L］(P<0.05)，而IL-6水平［(81±4) μg/L］高于健康对照组［(18±5) μg/L］(P<0.05)，APN水平与IL-6呈负相关(r=-0.782，P<0.05)。多元回归分析表明，收缩压、高血压分级和IL-6水平可显著影响原发性高血压患者血清APN水平的变化。结论： 原发性高血压患者存在低脂联素血症，且与高血压严重程度密切相关。
Abstract:
AIM:To explore the relationship between adiponectin and interleukin-6 (IL-6) in patients with essential hypertension (EH). METHODS: A total of 60 patients with EH (EH group, including 20 cases, respectively, of high blood pressure level 1, level 2 and level 3) and 20 healthy subjects (control group) were enrolled. Serum adiponectin and IL-6 concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: Serum adiponectin concentration in EH group was significantly lower than in control group ［(8.2±3.8) mg/L vs. (10.4±2.9) mg/L, P<0.05］. However, the serum level of IL-6 in the EH group was higher than in the control group ［(81±4) μg/L vs. (18±5) μg/L, P<0.05］. Serum adiponectin concentration was negatively correlated with IL-6 (r=-0.782, P<0.05). Multiple regression analysis revealed that systolic blood pressure, severity of hypertension and IL-6 level significantly affected serum adiponectin level. CONCLUSION: Hypoadiponectinemia is present in patients with EH and adiponectin concentration is closely related with the severity of hypertension.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-06-08.作者简介：曹世平，副主任医师，博士 Email：csp@fimmu.com
更新日期/Last Update: 2013-04-28