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Title:: Establishment of models with equalsized atrial septal defect in canines by puncturing method

作者:: 张婷婷¹; 万陈²; 成革胜¹; 和旭梅¹; 杜亚娟¹; 张玉顺¹; (1.西安交通大学医学院第一附属医院心内二科，陕西西安 710061；2.第三军医大学西南医院心内科，重庆 404100)

Author(s):: ZHANG Tingting¹; WAN Chen²; CHENG Gesheng¹; HE Xumei¹; DU Yajuan¹; ZHANG Yushun¹; (1.Department of Cardiology, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China; 2.Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing 404100, China)

关键词:: 房间隔缺损; 打孔法; 犬

Keywords:: atrial septal defect; puncturing method; canine

分类号:: R541.1

DOI:: -

文献标识码:: A

摘要:: 目的:探讨非体外循环房间隔打孔法建立犬同等大小房间隔缺损(ASD)动物模型的可行性。方法:将健康杂种犬9只开胸后，通过右心房心外膜触诊房间隔判断卵圆窝的位置。切开卵圆窝相对应的右心房壁，插入6 mm大小自制的房间隔打孔器并垂直推送打孔器穿刺房间隔，环形切割房间隔组织建立ASD模型。结果:9只犬的ASD模型均成功建立。2只犬术后解剖观察，ASD直径分别为6.0 mm和6.1 mm，与自制打孔器的大小相符，其余7只用经胸超声心动图(TTE)检查ASD直径为(6.0±0.2) mm，均为中央型ASD。全部犬均未发现心包积液等并发症。结论:以非体外循环房间隔打孔法可建立同等大小的ASD动物模型，本法成功率高、并发症少，值得推广。

Abstract:: To explore the feasibility of establishing animal models with equalsized atrial septal defect (ASD) in canines by puncturing method without cardiopulmonary bypass. METHODS: Nine healthy mongrel canines were chosen for the study. Atrial septum was palpated through the epicardial of the right atrial after thoracotomy to determine the position of the oval fossa, 6mm sized homemade atrial septal punchers were inserted, punchers were pushed vertically to puncture the atrial septum, atrial septum was cut annularly and ASD models were thus established. RESULTS: Operations were successful in all 9 dogs. Postoperation anatomy of two of the dogs showed that the ASD diameters in the two dogs were 60 mm and 61 mm respectively, which were almost equal with the size of the homemade punchers’s. TTE displayed that the ASD diameters in the other 7 dogs were (60±02) mm, and they were all centraltype ASD. No complications such as pericardial effusion were observed in the 9 dogs. CONCLUSION: Puncturing atrial septum is effective and safe in establishing equalsized ASD animal models without cardiopulmonary bypass.

参考文献/References

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打孔法建立犬同等大小房间隔缺损动物模型的研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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