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Title:: Levels of interleukin 17 and interleukin 10 in serum of atrial fibrillation patients

作者:: 果怡博¹; 曹威²; 李茜楠¹; 崔金金²; 李述峰²; 栾颖²; 田野¹; (哈尔滨医科大学：1.附属第一医院心内科，2.附属第二医院心内科，黑龙江哈尔滨 150000)

Author(s):: GUO Yi bo¹; CAO Wei²; LI Qian nan¹; CUI Jin jin²; LI Shu feng²; LUAN Ying²; TIAN Ye¹; (1.Department of Cardiology, First Affiliated Hospital, 2.Department of Cardiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang, China)

关键词:: 心房颤动; 白介素-17; 白介素-10; 炎症

Keywords:: atrial fibrillation; interleukin17; interleukin10; inflammation

分类号:: R541.71

DOI:: -

文献标识码:: A

摘要:: 目的:探讨左心房和右心房的白介素-17（IL-17）和白介素-10（IL-10）的水平与心房颤动（房颤）发生的关系。方法:选择42例房颤患者，其中阵发性房颤24例，持续性房颤18；选择阵发性室上速或预激综合征患者17例为对照组。通过ELISA方法检测左心房和右心房IL-10和IL-17水平，并使用心脏超声心动图测量左心房长径。分析血清中IL-10和IL-17细胞因子的水平与房颤左房结构重构程度的关系。结果:房颤组左心房和右心房IL-17明显高于对照组（均P<0.01）；房颤组IL-10显著高于对照组（左心房：P<0.01，右心房:P<0.05）。结论： IL-17、IL-10与房颤相关。 IL-17升高水平与左心房内径成正比。

Abstract:: AIM:To study the levels of IL-17 and IL-10 in left and right atrium serum of atrial fibrillation patients and to investigate their relation with the progression of atrial fibrillation. METHODS: Fortytwo atrial fibrillation patients, including 24 paroxysmal atrial fibrillation patients and 18 persistent atrial fibrillation patients and a control group of 17 selective paroxysmal supraventricular tachycardia or preexcitation syndrome patients were included in the study. The levels of IL-17 and IL-10 in serum from left and right atrium evaluated by ELISA and the left atrial long diameters measured by cardiac ultrasound heartbeat graph were used to study the association between IL-17 and IL-10 in serum and atrial fibrillation left atrial structural remodeling. RESULTS: The levels of the IL-17 and IL-10 in left and right atrium serum from atrial fibrillation patients were both higher than those from controls (P<0.01, P<0.01, P<0.01, P<0.05, respectively). CONCLUSION: IL-17 and IL-10 in serum are remarkably related to atrial fibrillation development, and they may play an important role in the progression of atrial fibrillation..

参考文献/References

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血清中白介素-17和白介素-10水平与心房颤动的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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