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|本期目录/Table of Contents|

NADPH氧化酶亚基在心脏重构中作用的比较

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第3期
页码:
383
栏目:
综述
出版日期:
2013-06-25

文章信息/Info

Title:
Contrasting roles of NADPH oxidase isoforms in cardiac remodeling
作者:
曹 妍; 赵德超; 赵晓宇
(哈尔滨医科大学附属第一医院心内科八病房，黑龙江 哈尔滨 150001)
Author(s):
CAO Yan;  ZHAO De chao;  ZHAO Xiao yu
(Department of Cardiology, First Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
心室重构; NADPH氧化酶; Nox2; Nox4
Keywords:
Cardiac remodeling;  NADPH oxidases;  Nox2;  Nox4.
分类号:
Q554.9
DOI:
-
文献标识码:
A
摘要:
早期研究证实，烟酰胺腺嘌呤二核苷酸（还原型辅酶Ⅱ，NADPH）氧化酶在血管紧张素Ⅱ（AngⅡ）介导的心室重构中发挥重要作用，随着对NADPH氧化酶的深入研究，发现其共有5种亚基和两种相关的亚基,其中在心脏组织中表达的主要为Nox2与Nox4。Nox2在AngⅡ、心肌梗死及阿霉素介导的心室重构中具有重要的促进作用，而在压力负荷过大时引起的左心室肥大中Nox4 mRNA表达上调明显，由此可得出NADPH氧化酶亚基Nox2与Nox4在心室重构中的作用不同。因此，深入研究NADPH氧化酶亚基及其在心室重构中的作用，将成为改善心室重构新的治疗靶点。
Abstract:
Early research demonstrated that NADPH oxidases was important in cardiac remodeling induced by AngII. In later studies, a total of five NOX enzymes and two related enzymes were discovered and two main isforms, Nox2 and Nox4, were found to have expressed in the heart. Nox2 could promote the development of cardiac remodeling induced by AngII, myocardial infarction and chemotherapeutic agent doxorubicin, while Nox4 mRNA increased significantly in pressureoverload left ventricular hypertrophy. Therefore, Nox2 and Nox4 play different roles in cardiac remodeling. A better understanding of these enzymes as well as their roles in cardiac remodeling may lead to new therapeutic targets based on modulation of Nox activity.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-12-26.
基金项目：黑龙江省自然科学基金资助(D201070)
通讯作者：赵德超，副主任医师，主要从事病毒性心肌炎发病机制的研究 Email：zhaodechao616@yahoo.com.cn
作者简介：曹妍，硕士生 Email：1092481743@qq.com
更新日期/Last Update: 2013-07-16