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|本期目录/Table of Contents|

脐带血干细胞移植治疗心血管疾病进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第4期
页码:
473-475498
栏目:
综述
出版日期:
2013-07-25

文章信息/Info

Title:
Progress of umbilical cord blood stem cell transplantation in treatment of cardiovascular diseases
作者:
公绪合; 王国干
（中国医学科学院、中国协和医科大学北京阜外心血管病医院急重症中心，北京 100037）
Author(s):
GONG Xu-he;  WANG Guo-gan
(Cardiovascular Institute & Center of Emergency of Fuwai Hospital, CAMS & PUMC, Beijing 100037, China)
关键词:
脐带血; 干细胞; 移植治疗; 心血管疾病
Keywords:
umbilical cord blood;  stem cell;  cell treatment;  progress
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
脐带血是妊娠时期连接母体和胎儿之间的通路,可提供胎儿重要的营养及氧气，被认为生命的连接线。除此之外，近年来脐带血干细胞移植治疗的作用引起关注,不仅对各种血液系统病变的治疗效果显著，而且由于脐带血干细胞分化的潜能，在治疗各种病理性病变如神经系统病变和心血管病变发挥着重要作用，已成为再生医学研究的一个重点。本文对脐带血干细胞移植相关的概念、细胞类型、临床试验及选择脐带血干细胞作为移植来源的优势和展望做一综述。
Abstract:
Umbilical cord is a linking pathway between the fetus and the mother in the pregnancy period and it provides important nutrients and oxygen. Umbilical cord is thus considered the life line. In recent years, more attention has been paid to its transplantation, which has significant treatment effects on various hematological diseases. Umbilical cord blood stem cells have strong differentiation potentials and they play an important role in regenerative medicine. This article discusses some related concepts of umbilical cord blood stem cells transplantation, cell types, clinical trials and the advantages of using umbilical cord blood stem cell as transplant source.

参考文献/References

[1]Felli N,Cianetti L,Pelosi E,et al.Hematopoietic differentiation:A coordinated dynamical process towards attractor stable states[J].BMC Syst Biol,2010,4:85.

[2]Liu G,Ye X,Zhu Y,et al.Osteogenic differentiation of GFP-labeled human umbilical cord blood derived mesenchymal stem cells after cryopreservation[J].Cryobiology,2011,63(2):125-128.

[3]Tio M,Tan KH,Lee W,et al.Roles of db-cAMP,IBMX and RA in aspects of neural differentiation of cord blood derived mesenchy-mal-like stem cells[J].PLoS One,2010,5(2):e9398.

[4]Ballen KK,Barker JN,Stewart SK,et al.Collection and preservation of cord blood for personal use[J].Biol Blood Marrow Transplant,2008,14(3):356-363.

[5]Kucia M,Halasa M,Wysoczynski M,et al.Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: Preliminary report[J].Leukemia,2007,21(2):297-303.

[6]Ali H,Jurga M,Kurgonaite K,et al.Defined serum-free culturing conditions for neural tissue engineering of human cord blood stem cells[J].Acta Neurobiologiae Experimentalis,2009,69(1):12-23.

[7]Mollmann H,Nef H,Elsasser A, et al. Stem cells in myocardial infarction: from bench to bedside［J］. Heart, 2009, 95(6):508-514.

[8]Henning RJ,Dennis S,Sawmiller D,et al.Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia[J].Transl Res,2012,159(6):497-506.

[9]Henning RJ,Burgos JD,Vasko M,et al.Human cord blood cells and myocardial infarction:effect of dose and route of administration on infarct size[J].Cell Transplant,2007,16(9):907-917.

[10]Ghodsizad A,Ungerer MN,Bordel V,et al.Transplanted human cord blood-derived unrestricted somatic stem cells preserve high-energy reserves at the site of acute myocardial infarction[J].Cytotherapy,2011,13(8):956-961.

[11]Iwasaki H,Kawamoto A,Willwerth C,et al.Therapeutic potential of unrestricted somatic stem cells isolated from placental cord blood for cardiac repair post myocardial infarction[J].Arterioscler Thromb Vasc Biol,2009,29(11):1830-1835.

[12]Moelker AD,Baks T,Wever KM,et al.Intracoronary delivery of umbilical cord blood derived unrestricted somatic stem cells is not suitable to improve LV function after myocardial infarction in swine[J].J Mol Cell Cardiol,2007,42(4):735-745.

[13]Stanevsky A,Goldstein G,Nagler A.Umbilical cord blood transplantation:pros, cons and beyond[J].Blood Rev,2009,23(5):199-204.

[14]Ringden O,Okas M,Uhlin M,et al.Unrelated cord blood and mismatched unrelated volunteer donor transplants, two alternatives in patients who lack an HLA-identical donor[J].Bone Marrow Transplant,2008,42(10):643-648.

[15]Ma LL,Meng FB,Shi P,et al.Higher Number and Proliferation Rate of Mesenchymal Stem Cells Are Found in Human Cord Blood of Non-full-term Gestation[J].Cell Biol Int,2012,36(4):415-418.

[16]Sibov TT,Severino P,Marti LC,et al.Mesenchymal stem cells from umbilical cord blood: parameters for isolation,characterization and adipogenic differentiation[J].Cytotechnology,2012,64(5):511-521.

[17]单 伟,张海锋,马云胜,等.接种密度对人脐静脉间充质干细胞原代培养的影响[J].医学理论与实践,2007,6（20）:627-629.

备注/Memo

备注/Memo:
收稿日期：2012-11-21.通讯作者：王国干，教授，主要从事心力衰竭、心肌炎及干细胞研究 Email：wangguog@263.net 作者简介：公绪合，博士生 Email：gongxuhe123@126.com
更新日期/Last Update: 2013-07-29