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|本期目录/Table of Contents|

血小板源性生长因子及其受体在心血管疾病中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第4期
页码:
482-485
栏目:
综述
出版日期:
2013-07-25

文章信息/Info

Title:
Roles of platelet-derived growth factors and platelet-derived growth factor receptors in cardiovascular diseases
作者:
范 彬 综述; 马礼坤 审校
(安徽医科大学附属省立医院心血管内科，安徽 合肥 230001)
Author(s):
FAN Bin;  MA Li-kun
(Department of Cardiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui, China)
关键词:
受体; 血小板源性生长因子; 心血管疾病; 动脉粥样硬化
Keywords:
receptors;  platelet-derived growth factors;  atherosclerosis;  angiogenesis;  myocardial fibrosis
分类号:
Q592.1
DOI:
-
文献标识码:
A
摘要:
血小板源性生成因子（PDGFs）及其受体（PDGFRs）在心血管疾病中发挥着重要作用，二者不仅参与了动脉粥样硬化（AS）的形成，而且在血管生成、心肌纤维化过程中也扮演了重要角色。PDGFRs被其配体PDGFs激活后，在血管平滑肌细胞、纤维母细胞、内皮细胞等中的表达上调，通过细胞内信号转导通路，促使该类靶细胞增殖分化，从而参与AS、血管生成和心肌纤维化的发生。本文就PDGFs/PDGFRs在心血管疾病中的研究进展做一综述。
Abstract:
Platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) both play some important roles in the cardiovascular diseases, including atherosclerosis (AS), angiogenesis and myocardial fibrosis. PDGFRs which are activated by their ligand PDGFs up-regulate in cells, such as vascular smooth muscle cells, fibroblasts and endothelial cells, thus resulting in the proliferation and differentiation of target cells. PDGFs/PDGFRs participate in AS angiogenesis and myocardial fibrosis. This review will discuss the research progress of PDGFs/PDGFRs in the cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期：2012-09-24.通讯作者：马礼坤，主任医师，主要从事冠状动脉粥样硬化 研究 Email：lkma08@yahoo.cn 作者简介：范彬，硕士生 Email：fanbin414@163.com
更新日期/Last Update: 2013-07-29